The invention discloses hybrid TPU capable of quickly crystallizing and having a low refractive index and a preparation method of the hybrid TPU. The preparation method comprises the steps: (1) preparing hollow silicon dioxide nano-microspheres with high alcohol modified on the surfaces; and (2) adding isocyanate (MDI), the hollow silicon dioxide nano-microspheres and a catalyst into a reactor under the protection of nitrogen and heating to prepare a hollow silicon dioxide microsphere hybridized TPU prepolymer, wherein the mass fraction of the isocyanate is 20-60%. The refractive index of the TPU is reduced to about 1.45, and the TPU has low refractive index, can filter various glare, stray light, refracted light, reflected light, scattered light and the like in front of an automobile when being applied to an automobile strong windshield, and reduces the fatigue feeling caused by long-time driving; and in addition, the hollow silicon dioxide nano-microspheres have surface crystallizable and plasticizable properties, so that the processing difficulty of the polymer is not increased, the crystallization rate of the polymer is improved, the forming time of the product is shortened, and the processing and manufacturing cost can be saved.