The invention discloses a DC-DC module power supply which comprises an enclosure and a circuit mainboard arranged in the enclosure, the circuit mainboard comprises a primary-side circuit and a secondary-side circuit, the primary-side circuit comprises a power conversion circuit, a primary-side driving circuit and a primary-side control circuit, the power conversion circuit adopts a high-frequency power switch, an input DC voltage of 185-340V DC is converted into a 9V low-voltage DC output voltage by a transformer, the secondary-side circuit comprises a synchronous rectification circuit, a secondary-side driving circuit, a secondary-side control circuit and an isolation switch, the synchronous rectification circuit adopts a synchronous rectification switch for synchronous rectification, a low-voltage power pulse is converted into a smooth 9V DC through an output filter, and the smooth 9V DC is output through an anode confluence structure and a cathode confluence structure. The mainboard is reasonable in arrangement and compact in structure, has the advantages of small volume, high reliability, good heat dissipation performance, high anti-interference capability, high isolation and the like, and is mainly applicable for the fields such communication, aeronautics and astronautics and military.