Disclosed is a pneumatic actuator control high pressure ball valve. The ball valve comprises a lower connecting joint, a valve body, a base support, an upper cover, an O-shaped sealing ring, an adjusting butterfly spring, a reinforced PPL synthetic sealing material, a spherical valve element, a sealing gasket, packing, a valve rod, hexagon bolts, a bracket, a pneumatic control device and a ball base sealing ring; the valve body is a transverse thick cylinder, the thick cylinder of the valve body is provided with an inlet and an outlet of the valve, and the inlet and the outlet are connected with end joints; the spherical valve element is arranged in the center of the valve body, left and right ball base sealing rings communicated with the inlet and outlet are located at the inlet and outlet which are formed in the left and right portions of the valve body, and the bracket is arranged on the combined packing and fixed to the upper cover of the valve body through screws at the upper end;the pneumatic control device is arranged above the bracket; the pneumatic control device outputs rotational driving torque to the valve rod.