The invention discloses a multifunctional fresh air mullion which comprises a fresh air mullion body and a movable glass inlay stopper. The movable glass inlay stopper is connected with the side surface of the fresh air mullion body through screws, end covers are arranged at the upper end and the lower end of the fresh air mullion body, the fresh air mullion body is divided into an electric ventilation part, an electric control part, a manual control part and a natural ventilation part from top to bottom, a first ventilation grilling and a second ventilation grilling are arranged in the fresh air mullion body, and the fresh air mullion body is divided into an outdoor air inlet cavity, a middle cavity and a filter cavity by the first ventilation grilling and the second ventilation grilling from an outdoor side to an indoor side. The multifunctional fresh air mullion has bearing, strengthening, dividing and decorating functions on door and window mullion when being applied to doors and windows and can serve as an indoor fresh air system, filtered, heated and sterilized outdoor air is led into the indoor spaces, window sashes cannot be opened, so that the indoor air and the outdoor air can be circularly interacted, the indoor air always keeps clean and fresh, and indoor air quality can be improved.