The invention belongs to the field of water production, and relates to a mixed bed regeneration improvement process, a system and application. The process comprises air scrubbing, backwashing pre-layering, primary drainage, alkali feeding failure, backwashing layering, standing, secondary drainage, pre-injection, acid and alkali feeding, replacement, after-replacement drainage, regeneration mixing, regeneration irrigation, regeneration forward washing, and operation. The backwashing effect is enhanced by compressed-air scrubbing, so that the resin is fully loosened. The subsequent backwashingis facilitated. Meanwhile, in the alkali feeding failure step, the alkali feeding mode is adjusted, a positive discharge valve is changed into a middle discharge valve, alkali can fully and only exchange with upper-layer anion resin, meanwhile, a small amount of upper-layer cation resin fails, the alkali feeding time is shortened, the alkali consumption can be reduced, and the regeneration effectis improved.