The invention discloses a downward layering horizontal drift high-sublevel filling mining method. The downward layering horizontal drift high-sublevel filling mining method particularly comprises thesteps of division of ore blocks, stope preparation cutting, stoping, stope ventilation and stope filling and so on, and a whole sublevel mine can be mined. The sublevel height is increased, the stoping layer number is increased, the sublevel stoping mine amount is increased, the panel service life can be prolonged, panel mining disorder can be solved, after middle level stope preparation engineering arranging optimization, six sublevels are arranged in the 150 m middle level, the sublevel construction is reduced, the middle level stope preparation engineering amount is reduced by about 3500m/72000m<3>, the mine engineering construction investment is greatly saved, after the sublevel height is increased, the sublevel service life is prolonged, the sublevel digging disorder contradiction isrelieved, and the sublevel engineering construction pressure is reduced.