The invention relates to a heat pump large-diameter heat exchange device and a system thereof for sewage or earth surface water source, in particular to a heat exchange device and a system thereof for picking up heat or refrigeration in sewage or earth surface water by a heat pump technology. The invention aims at solving the key problems of suspended matter blockage, complex process flow, large area occupation, and the like of the traditional technology for preventing blockage. The device provided by the invention is composed of two monomer heat exchange devices in series, wherein the monomer heat exchange device comprises a large-diameter tube, a tube plate, a shell, an inside baffle plate, an outside baffle plate, a sewage or earth surface water inlet, a sewage or earth surface water outlet, a cleaning water inlet, a cleaning water outlet, a sealing plate, and the like. The system comprises the heat exchange device, a heat pump set, a water pump, connecting pipelines, and the like. Sewage or earth surface water flows smoothly in the large-diameter tube, and cleaning water is in a counter-current flow with the sewage outside the tube. The heat pump set then picks up heat from the cleaning water. The invention is suitable for indirect systems of heat pumps for sewage or earth surface water source, and the front end does not need to be provided with a filter screen or a blockage prevention device. The invention realizes blockless continuous heat exchange and heat picking, and has the advantages of sufficient corrosion allowance, little area occupation, high heat exchange efficiency, and the like.