The invention discloses a full-wave nuclear magnetic resonance signal denoising method based on independent component analysis. The full-wave nuclear magnetic resonance signal denoising method is mainly used for power frequency harmonic interference or certain single-frequency interference in full-wave nuclear magnetic resonance signals. The method comprises the steps that firstly, utilizing a nuclear magnetic resonance sounding water detecting instrument for collecting MRS signals, obtaining the frequency of power frequency harmonic interference or certain single-frequency interference contained in the collected signals through spectral analysis, and adopting a digital orthogonal method for constructing input channel signals to solve the underdetermined blind source separation problem; then, using the constructed input channel signals and the collected MRS signals as input signals for conducting independent component analysis to obtain separated MRS signals; finally, adopting the spectrum correcting method for solving the problem that the separated MRS signals have uncertain amplitude, and then extracting denoised MRS signals. According to the full-wave nuclear magnetic resonance signal denoising method, the problem of the underdetermined blind source and the problem of the uncertain amplitude usually existing in independent component analysis are solved, the power frequency harmonic interference or the certain single-frequency interference in the noised MRS signals is effectively filtered out, and compared with a traditional MRS signal denoising method, the full-wave nuclear magnetic resonance signal denoising method has the advantages of being high in arithmetic speed, high in signal to noise ratio, high in practicability and the like.