52 results about "Triaziquone" patented technology

The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.

The invention discloses a synthesis method of a 1,2,3-phentriazine-4(3H)-one compound. 2-aminobenzamide and are used as raw materials and tert-butyl nitrite stirred at the room temperature in a reaction solvent, and the 1,2,3-phentriazine-4(3H)-one compound is obtained through an intramolecular diazotization reaction. The reaction equation is shown in the description, wherein R is H, fluorine, chlorine, bromine, trifluoromethyl, nitryl or methyl. The synthesis method has the benefits as follows: (1) the synthesis method is convenient in experiment operation, easy in posttreatment, mild in reaction condition and suitable of large-scale industrial production; (2) reaction substrate functional groups have high tolerance, and the substrate is wide in range and easy to obtain; (3) the reactionefficiency, yield and purity are higher.

The invention relates to a 4-phenoxy pyridine derivative containing a 3-pyridazinone structure, a 4-pyridazinone structure and a 1,2,4-triazinone structure, and applications thereof. According to theinvention, the 4-phenoxy pyridine derivative has a structure represented by a general formula (I), and the compound has strong inhibiting effect on c-Met kinase. The invention further relates to applications of the compound, the pharmaceutically acceptable salt, the hydrate, the solvate or the prodrug thereof in preparation of drugs for treating and/or preventing diseases caused by abnormal high expression of c-Met kinase, especially in preparation of drugs for treating and/or preventing cancers.

The present invention concerns a topical, cosmetic or pharmaceutical preparation containing a combination of 3 or 4 solar filters comprising: -one or two UVA filters to obtain a critical wavelength >370 nm, chosen from among: ( i) - 5, 6, 5, 6-tetraphenyl-3, 3'-(1,4-phenylene)-bis[1, 2, 4]triazine; (ii) 1,1'-(1,4-piperazinediyl)bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone; (iii)- Butyl Methoxydibenzoylmethane (BMDBM), in a quantity less than 2% by weight with regard to the total weight of said composition; (iv) - Hexyl -[4-(diethylamino)-2- hydroxybenzoyl]benzoate, -2,4-Bis[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6- (4-methoxyphenyl)-1, 3, 5-triazine = (BEMT), - one or two selected from the group consisting of diethylhexyl butamido triazone, ethylhexyl triazone, and filtersof tris-biphenyl triazine, ethylhexyl salicylate, phenylbenzimidazole sulfonic acid and TiO2 in an amount of from 3% by weight to 7% by weight relative to the total weight of the composition.

The present invention relates to salt forms and derivatives of 2-methylthio-6-nitro-1,2,4-triazoio[5,1-c]1,2,4-triazine -7-one, dehydrate and pharmaceutical compositions thereof. These salt forms and derivatives exhibit improved antiviral activity. The present invention also relates to processes for preparing the compounds, and intermediates used in their preparation.

The invention discloses a preparation method of 4-amino-6-tert-butyl-3-methylthio-1,2,4-triazine 5 (4H)-ketone. The method comprises steps of: reacting 4-amino-6-tert-butyl-3-sulfydryl-1,2,4-triazine-5 (4H)-ketone, dimethyl sulfate and anhydrous sodium carbonate in a molar ratio of 1:1.1-1.4:1.5-2 in a solvent acetone and in the presence of a catalyst potassium iodide at 15-45 DEG C for 2-4 h; and finally recovering acetone, adding water to dilute the material, separating and drying to obtain the 4-amino-6-tert-butyl-3-methylthio-1,2,4-triazine 5 (4H)-ketone. The raw materials used in the method are easily available, and cheap; and the method provided by the invention has advantages of moderate reaction and easily controlled reaction parameters, and can guarantee the safety of the production process. Potassium iodide is used as a catalyst, so as to realize rapid complete reaction at room temperature, reduce the production cycle and effectively reduce production cost; the product yield reaches more than 90%, and products with content of more than 96% can be directly obtained. The preparation method satisfies requirements of industrial production, and has a good application prospect.

The invention discloses a synthesis method of trinitrobenzo [4, 5] imidazo [2, 1-c] [1, 2, 4] triazine-4-one, and the method comprises the following steps: adding concentrated sulfuric acid into a reaction flask at low temperature, adding 3-nitro-4-amino-benzo [4, 5] imidazo [2, 1-c] [1, 2, 4] triazine in batches, and stirring; dropwise adding fuming nitric acid, heating to obtain a first reactionsystem after the reaction is finished, pouring the first reaction system into ice water, extracting a water phase by using ethyl acetate, combining organic phases, drying with anhydrous sodium sulfate, concentrating the organic phases to obtain a crude product, and further purifying the crude product through column chromatography to obtain 3, 7, 9-trinitrobenzo [4, 5] imidazo [2, 1-C] [1, 2, 4] triazine-4 (3H)-one and 3, 9-dinitrobenzo [4, 5] imidazo [2, 1-C] [1, 2, 4] triazine-4 (3H)-one. The raw material 2-aminobenzimidazole used in the reaction is a commercialized product in the market, and is low in price and easy to obtain.

The invention provides novel compounds having the general formula:

wherein R¹, R², R³, X and a are as described in the description and in the claims, as well as or pharmaceutically acceptable salts thereof. The invention also contains compositions including the compounds and methods of using the compounds.

The invention relates to the field of pesticides, and discloses a preparation method of 3, 3-dimethyl-2-oxobutyric acid and triazinone. The preparation method of the 3, 3-dimethyl-2-oxobutyric acid provided by the invention comprises the step of oxidizing the 3, 3-dimethyl-2-oxobutyric acid and/or a salt thereof by taking oxygen-containing gas as an oxidizing agent in the presence of a catalyst under the condition that the pH value is 7-13. According to the method disclosed by the invention, the 3, 3-dimethyl-2-hydroxybutyric acid and/or the salt thereof is taken as the raw material, and oxygen or air is used for replacing other oxidants, so that high-salinity wastewater and solid waste are avoided, the cost of the raw material is reduced, and the method is simple to operate and suitable for industrial production.

The invention relates to a coupling complexing extraction agent composition and a method for treating triazinone production wastewater. The composition comprises a first composition and a second composition, the first composition comprises a first complexing agent and a first diluent; the second composition comprises a second complexing agent and a second diluent; the first complexing agent comprises at least one of N503, butyl dibutyl phosphate, quaternary ammonium chloride and tertiary amine; and the second complexing agent comprises at least one of naphthenic acid and 2-ethylhexyl phosphoric acid. The method comprises the following steps: adjusting the pH value of triazinone production wastewater to 2-4, adding a first composition, reacting, and layering to obtain an upper-layer first extraction phase and a lower-layer first water phase; and adjusting the pH value of the first water phase to 6-8, adding a second composition, reacting, and layering to obtain an upper-layer second extraction phase and a lower-layer second water phase. According to the method, organic acid, organic alkali and other toxic organic pollutants in the wastewater can be extracted and separated, the COD removal rate is higher than that in the prior art, and water obtained after complexing extraction can be reused in the production process.

The invention relates to the technical field of chemical engineering, in particular to a triazinone production line. The triazinone production line comprises a hydrolysis kettle, wherein an oxidationkettle is arranged on and communicates with the hydrolysis kettle through a first connecting pipe; a cyclization kettle is arranged on and communicates with the oxidation kettle through a second connecting pipe; a middle kettle is arranged on and communicates with the cyclization kettle through a third connecting pipe; the first connecting pipe, the second connecting pipe and the third connectingpipe are each provided with a first pump body and a first valve; the middle kettle is connected with a centrifugal machine through a fourth connecting pipe in a communicating mode; a solid material discharging port of the centrifugal machine is provided with a material guiding pipe in a communicating mode; the material guiding pipe is provided with an air pump; a shell is arranged on the materialguiding pipe in a communicating mode; the lower end of the shell is fixedly connected with a supporting base; the bottom wall of the shell is rotationally connected with a connecting cylinder througha sealing bearing; a plurality of connecting pipes are arranged on the connecting cylinder in a communicating mode; and the lower end of the connecting cylinder is rotationally connected with a connecting cover through the sealing bearing. The invention also provides a preparation method of triazinone. According to the invention, particulate matters are prevented from adhering to each other and becoming lumps, so product quality is not influenced.

The invention discloses a synthesis method of 4-amino-6-tert-butyl-3-methylthio-1,2,4-triazin-5(4H)-one, which comprises a molar ratio of 1:1.05 ~1.5:1.5~2 of 4-amino-6-tert-butyl-3-mercapto-1,2,4-triazin-5(4H)-one, dimethyl sulfate and anhydrous sodium carbonate, solvent acetone, Catalyst potassium iodide, heat preservation reaction at 15-45°C for 2-5 hours, finally recover acetone, add water to precipitate, separate and dry to obtain 4-amino-6-tert-butyl-3-methylthio-1,2,4- Triazin-5(4H)-one. The raw materials used in the method of the present invention are easy to get, and the price is low; The method of the present invention has mild reaction, easy control of reaction parameters, and can ensure the safety of the production process; Potassium iodide is used as the catalyst, which makes the rapid reaction complete at normal temperature, greatly reducing the Its production cycle effectively reduces the production cost; the product yield is high, reaching over 90%, and products with a content of over 96% can be directly obtained, which meets the requirements of industrial production and has a good application prospect.

The invention relates to a recycling method of waste acid water from metribuzin production, which comprises the following steps: (1) extracting the waste acid water from metribuzin production to recover part of triazinone and metribuzin and reduce organic matters in the waste acid water; (2) carrying out aeration stripping on the extracted waste acid water to remove low-boiling-point substances such as methanol; (3) removing insoluble substances in the waste acid water subjected to aeration stripping; (4) performing resin adsorption on the waste acid water treated in the step (3) to remove residual organic matters, reducing the COD of the waste acid water from 4000-5000mg/L to 1000mg/L or below, changing the original wastewater color from yellow to faint yellow, and basically eliminating the odor of the waste acid water; and (5) concentrating the waste acid water subjected to resin adsorption to obtain concentrated sulfuric acid. According to the method, the waste acid water can be treated into the concentrated sulfuric acid capable of being recycled, treatment equipment is simple, energy consumption is low, and under the increasingly severe environment-friendly situation, high practicability and economical efficiency are achieved.

The invention discloses a preparation method of a sun-screening agent octyl triazinone, octyl triazinone prepared by the preparation method and an application of octyl triazinone, and the method comprises the following steps: step 1, carrying out esterification reaction on p-nitrobenzoic acid and isooctyl alcohol to obtain a product I, 2, carrying out a hydrogenation reaction on the product I in the presence of a catalyst, filtering after the reaction is completed, and carrying out reduced pressure distillation to obtain a product II, and step 3, adding a solvent into the product II, heating to reflux, adding the solution A, carrying out a reaction, and carrying out post-treatment to obtain octyltriazinone. Cheap and easily available p-nitrobenzoic acid is used as a raw material, the sun-screening agent octyl triazinone is efficiently prepared through esterification, hydrogenation and coupling, meanwhile, iso-octyl p-aminobenzoate is obtained, the obtained octyl triazinone is high in chromatographic purity and yield, and the method has the advantages of being few in three wastes, low in cost, green, environmentally friendly, easy to operate, easy to control and the like.Easy realization of industrial production.

The invention provides a novel metribuzin synthesis method which comprises the following steps: (1) adding 6-tert-butyl-4-amino-3-sulfydryl-1, 2, 4-triazine-5 (4H)-ketone into a certain amount of sulfuric acid in batches, and heating until the 6-tert-butyl-4-amino-3-sulfydryl-1, 2, 4-triazine-5 (4H)-ketone is completely dissolved and clarified; 2) cooling to a certain feeding temperature, adding acertain amount of methanol, controlling the temperature to a certain temperature, carrying out a heat preservation reaction for a period of time, and cooling the reaction material to a certain temperature for post-treatment; 3) dropwise adding a certain amount of water into the reaction material, and separating out a large amount of material, namely metribuzin sulfate; and 4) suspending the precipitated metribuzin sulfate in a certain amount of solvent, then adding alkali for neutralization, standing for layering, slowly cooling an organic phase for crystallization, and filtering to obtain high-purity metribuzin. The method is smooth in process, mild in condition and environmentally friendly, metribuzin with the purity of 98% or above can be directly obtained, and the yield can reach 85%or above.