13 results about "Triaziquone" patented technology

The invention relates to a composition comprising (i) more than 0.5 wt.% of a compound according to formula (Ia) or a salt, hydrate, stereoisomer, tautomer or N-oxide thereof, based on the total weight of the composition, and (ii) 4,4ʼ,4ʼʼ-(1,3,5-triazin-2,4,6-triyltriimino)tris-benzoic acid tris(2-ethylhexyl)ester (INCI ethylhexyl triazone).

The invention discloses a preparation method of 4-amino-6-tert-butyl-3-sulfydryl-1, 2, 4-triazine-5 (4H)-ketone and a preparation method of the 4-amino-6-tert-butyl-3-sulfydryl-1, 2, 4-triazine-5 (4H) The preparation method comprises the following steps: dissolving 3, 3-dimethyl-2-oxobutyric acid methyl ester in a solvent, adjusting the pH value to be acidic, then adding thiocarbazide and DMAP (Dimethylamino Phosphate), carrying out a heating reaction, and after the reaction is finished, carrying out filtering, solid separation, washing and vacuum drying in sequence to prepare 4-amino-6-tert-butyl-3-sulfydryl-1, 2, 4-triazine-5 (4H)-ketone. The extraction solvents used in all the steps are the same, the reaction solvent is mainly water and can be removed through anhydrous sodium sulfate, and when the reaction solvent is alcohol, the alcohol can be removed through rotary evaporation. Therefore, the discharge amount of three wastes in the reaction is small, the potential safety hazard is small, and the product yield and purity are high; raw material cost is low, and industrial production is facilitated.

The invention discloses a chiral pyrazolo [1, 3-a] [1, 2, 4] triazine-6-ketone compound and a preparation method of the chiral pyrazolo [1, 3-a] [1, 2, 4] triazine-6-ketone compound. According to the method, under the action of a copper catalyst generated in situ by a metal copper precursor and a chiral pyridine bisoxazoline ligand in a reaction medium, an ethynyl methylene cyclocarbamate compound and an azomethine compound are subjected to a [3 + 3] cyclization reaction, and the chiral pyrazolo [1, 3-a] [1, 2, 4] triazine-6-ketone compound is obtained with high yield and high enantioselectivity. The method has the characteristics of cheap catalyst precursor, easily available ligand, high activity, high selectivity, mild reaction conditions, simplicity and convenience in operation and the like.

The invention discloses a triazinone compound and medical application thereof.The compound shown in the formula I and pharmaceutically acceptable salt of the compound can serve as an NLRP3 inflammasome inhibitor and can be used for preparing drugs for preventing or treating NLRP3 inflammasome mediated diseases.

The utility model discloses a triazinone hydrolysis device which comprises a reaction kettle, the upper surface of the reaction kettle is fixedly connected with a motor, the output end of the motor is fixedly connected with a rotating column, the outer surface of the rotating column is fixedly connected with four inclined scrapers, the middle of the outer surface of the reaction kettle is fixedly connected with an oil collecting block, and the oil collecting block is fixedly connected with an oil outlet of the oil collecting block. An oil removing groove is formed in the oil collecting block, the oil removing groove is communicated with the interior of the reaction kettle, in-groove baffles are fixedly connected to the lower surfaces of the four inclined scraping plates, the in-groove baffles are located in the oil removing groove, and four oil removing pipes are fixedly connected to the lower surface of the oil collecting block; oil storage pipes are fixedly connected to the lower surfaces of the four oil removing pipes, oil outlet pipes are fixedly connected to the lower surfaces of the oil storage pipes, and mechanical valves are fixedly connected to the interiors of the oil outlet pipes. The inclined scraping plate rotates along with the rotation of the rotating column, and the oil dirt moves in the specific direction along the track of the scraping plate by utilizing the inclination angle and the rotating force, so that the oil dirt collecting efficiency is improved.

The present application relates to compounds of Formula (I), wherein P, Q, A, B, m, n, R1, R2 and R3 are defined as in Formula (I) which are negative allosteric modulators of the metabotropic glutamate receptor subtype 7 (mGlu7) and which are useful for the treatment or prevention of neurological, ear and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGlu7 subtype of metabotropic receptors is involved. The application is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and such compositions, and to the use of such compounds for the prevention or treatment of neurological, ear and psychiatric disorders and diseases in which mGlu7 is involved.

The embodiment of the invention discloses a method for determining multiple sun-screening agents in serum, the method can be used for determining the sun-screening agents, and the method comprises the following steps: obtaining a to-be-detected sample according to to-be-detected serum; performing chromatography and mass spectrometry on the to-be-detected sample under a predetermined detection condition to obtain peak area data corresponding to the multiple sun-screening agents; acquiring the concentration of each sun-screening agent in the serum to be detected according to the linear equation and the peak area data of each sun-screening agent; the multiple sun-screening agents comprise at least one of cresol trozole trisiloxane and ethyl hexyl triazinone.

The present disclosure provides pyrazolo[5,1-f][1,2,4]triazin-4-ones that are inhibitors of NOX4, and are therefore useful for the treatment of diseases treatable by inhibition of NOX4. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

The present invention relates to a cosmetic or pharmaceutical composition comprising at least one cosmetically or pharmaceutically acceptable excipient and a photoprotective system consisting of: (a) 5,6,5′,6′-tetraphenyl-3,3′-(1,4-phenylene)-bis[1,2,4]triazine, (b) 2,4-bis[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, (c) hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate, and (d) a solar filter selected from the group comprised of ethylhexyl triazone, diethylhexyl butamido triazone and 2-ethylhexyl salicylate, wherein the photoprotective system represents between 4% and 20% by weight of the composition relative to the total weight of the composition.

This invention relates to the fields of compound synthesis technology and pesticide technology, specifically to N-phenylthiotriazinone derivatives, their preparation methods, and applications. The N-phenylthiotriazinone derivatives are either N-phenylthiotriazinone derivatives containing oxime ester groups or N-phenylthiotriazinone derivatives containing oxime ether groups. The N-phenylthiotriazinone derivatives of this invention exhibit 100% control efficacy against six weeds at doses of 37.5-150 a.g. / ha. These compounds achieve good weed control effects at low doses and have relatively good safety profiles for crops such as corn, wheat, peanuts, soybeans, and cotton. They can be used as selective herbicides in agriculture. The compounds described in this invention can be developed and used as potential PPO inhibitors and post-emergence herbicides for broadleaf weeds. The derivatives have simple structures and preparation processes, low production costs, and broad application prospects.

The present disclosure provides pyrazolo[5,1-f][1,2,4]triazin-4-ones that are inhibitors of NOX4, and are therefore useful for the treatment of diseases treatable by inhibition of NOX4. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

The present invention relates to a sunscreen or daily care composition, the sunscreen or daily care composition comprising: (i) dicocoyl pentaerythritol distearyl citrate; and (ii) at least one organic UV filter, the present invention relates to a composition selected from the group consisting of disodium phenyl dibenzimidazole tetrasulfonate (DPDT), hexyl diethylaminohydroxybenzoylbenzoate (DHHB), butyl methoxydibenzoylmethane (BMDBM), p-xylylenedicamphorsulfonic acid (TDSA), ethylhexyl triazinone (EHT), diethylhexyl butyramido triazinone (DBT), phenylbenzimidazole sulfonic acid (PBSA), and one or more additives selected from the group consisting of: disodium phenyl dibenzimidazole tetrasulfonate (DPDT); the present invention relates to a pharmaceutical composition, in particular, a pharmaceutical composition comprising: a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, and a silicone rubber composition comprising a silicone rubber composition, a silicone rubber composition comprising a silicone rubber composition, and a silicone rubber composition comprising a silicone rubber composition, furthermore, the present invention relates to the use of dicocoyl pentaerythritol distearyl citrate for improving the sun protection factor (SPF) and water resistance of a sunscreen or daily care composition comprising at least one organic UV filter and a corresponding method of use.