The invention belongs to the technical field of energy and power, in particular to an unattended operation type monitoring system and method for organic Rankine cycle isolated network power generation. According to the unattended operation type monitoring system and method for organic Rankine cycle isolated network power generation, automation control of the monitoring system for organic Rankine cycle isolated network power generation and system malfunction automatic processing are achieved. The monitoring system comprises a flowmeter, pressure sensors, temperature sensors, a working medium pump, an evaporator, an electric three-way valve, an expansion machine, a power generator, a condenser, a heat source circuit, a cooling circuit, a touch screen, a PLC unit, a working medium pump frequency converter, a relay, a warner and a multifunctional electrodynamic meter. Through real-time state monitoring of a unit, under instable heat-source and cold-source fluctuation, stabile, reliable and efficient operation of a waste heat power generation system is achieved. According to the unattended operation type monitoring system and method, while good self-adaption is achieved, automatic adjusting can be conducted when the system malfunctions, and unattended operation of an isolated network power generation system is achieved.