3results about How to "Avoid compensation" patented technology

This invention relates to the field of radiotherapy technology, and particularly to a method for dose correction and compensator co-optimization in FLASH radiotherapy. The method includes constructing an objective function using the corrected target dose and actual dose in the target area; integrating the objective function with a process constraint penalty function for the compensator thickness to generate an optimization function and determining the constraint conditions; calculating the gradient of the updated optimization function with respect to the beam intensity; calculating the compensator thickness based on the updated beam intensity; verifying the compensator thickness according to the constraint conditions; determining whether the dose deviation meets dose convergence requirements based on the optimized beam intensity and compensator thickness; and outputting an optimized scheme based on the result of whether the compensator thickness meets the constraint conditions. This invention can avoid overcompensation or undercompensation of the target area, preserving the normal tissue protection effect of FLASH radiotherapy, and simultaneously solving the problem in traditional technologies where the dose is within the target range but the compensator cannot be manufactured, thus improving the feasibility of FLASH radiotherapy treatment plans.

The utility model discloses adjustable linkage anti-inversion limiting hip external rotation orthopedic shoe cover, including first shoe cover, second shoe cover, two groups of clamping devices, restraint belt and two connecting devices, wherein, first shoe cover and second shoe cover are set up respectively corresponding patient left and right foot, and two groups of symmetrical clamping devices are fixedly arranged respectively in the lateral end of first shoe cover and second shoe cover, and each group of clamping devices includes a plurality of insertion holes along the longitudinal arrangement of shoe cover and the clamping assembly that cooperates with insertion hole, and the clamping assembly is slidably arranged above insertion hole, and two connecting devices all include connecting head and connecting assembly, wherein, one end of connecting assembly is fixedly connected with connecting head, and the other end can selectively insert any insertion hole and form the clamping fixed with corresponding clamping assembly. Therefore, through double shoe cover clamping linkage structure and adjustable restraint belt, the coherent mechanical constraint system from foot to lower limb is formed, and the collaborative correction to foot inversion and hip external rotation is realized.

The invention relates to a construction method and application of a mouse model with spontaneous gastric precancerous lesions. The construction method comprises the following steps: constructing a Pgc-Cre gene mouse only carrying an inducible Cre gene (tamoxifen can be injected in a rich manner to induce Cre nucleation); the method comprises the following steps: constructing a Rosa26-Zeb2 gene mouse which only carries a Zeb2 gene; the method comprises the following steps: taking Cre and Zeb2 genes as raw materials, mating to obtain a mouse carrying the Cre and Zeb2 genes at the same time, then administering a drug to the mouse, inducing Cre to enter a nucleus and promoting expression of the Zeb2 genes to obtain the mouse model with the spontaneous precancerous lesion of the gastric cancer; the medicine is tamoxifen. The mouse model constructed by the invention is driven by the specific inducible Cre of the stomach main cells, is limited to the stomach main cells, avoids gene disturbance of non-target cells, is simple and convenient to mate, low in cost and short in experimental period, and can be used for screening gastric precancerous lesion drugs.