The invention belongs to the technical field of medical auxiliary appliances, and particularly relates to a post-epidermis transplantation receiving area wound surface protection device for vitiligo treatment, which comprises an external protection shell, three straight notches are formed in the outer circumferential surface of the external protection shell, and guide chutes are formed in the left and right side surfaces of the inner walls of the three straight notches; sliding base blocks are arranged in the three straight notches, the left sides and the right sides of the sliding base blocks are slidably connected with the guiding sliding grooves correspondingly, and adjusting and controlling bolts are installed on the upper surfaces of the sliding base blocks in a threaded mode. The covering and fixing use of a forearm skin-receiving area can be completed by utilizing a covering and pressing spring, the situation that healing is affected by displacement of the skin-receiving area is effectively prevented, the forearm of a user and an external protection shell are connected, limited and fixed through an air bag and an air bag strip, and the isolation protection use of the forearm is completed through the external protection shell; therefore, the wound surface of the receiving area after epidermis transplantation during vitiligo treatment is protected.