30results about How to "Generate less waste" patented technology

The present invention discloses a preparation method for optical activity active 3-amino butanol and optical activity 3-amino butyric acid. The optical activity active 3-amino butanol preparation method comprises: in a solvent, under effects of a hydroboration reduction agent and a Lewis acid, carrying out a reduction reaction on a compound represented by a formlu 65 to produce a compound represented by a formlu 14. The optical activity active 3-amino butyric acid preparation method comprises: carrying out a hydrolysis reaction on a compound represented by a formlu 64 to produce a compound represented by a formlu 65. According to the present invention, the preparation method has characteristics of cheap and easily-available raw materials, simple operation, short process route, no hazard of raw materials, high yield, little waste production, environment protection, high raw material conversion rate, high product chemical purity and high product optical purity, and the industrialization is easily achieved. The formulas 64, 65 and 14 are defined in the instruction.

A wristband is assembled from a flexible preferably vinyl carrier and a preferably laminated ID label, the carrier having a panel portion and a strap portion with a snap closure located in a toe extension at the end of the carrier adjacent the panel. The strap has a series of holes, one of which is captured within the snap closure to attach the wristband to the wearer's limb. The laminated ID label has a pair of opposing slots, one of which slips over the strap to abut the panel and the other of which is captured by the snap closure to attach the label to the carrier. The panel portion has a relieved edge formed along its opposing sides which increases the comfort of the wristband as it is worn.

The invention relates to the field of welding material manufacturing, in particular to a manufacturing method of novel solid welding wires. The method starting from wire rod machining sequentially includes: forging, annealing, continuously wire drawing, scraping, and ultrasonic wave cleaning to obtain the solid welding wires which are bright and fine-grain. The solid welding wires include various non-ferrous metal and non-ferrous metal alloy welding wires. The manufactured solid welding wires have fine and even equiaxed grains on the transverse end faces and the longitudinal end faces, product strength and plasticity are increased evidently compared with other manufacturing methods, and excellent mechanical property is achieved. In addition, the manufacturing method is simple in process, low in waste material, high in yield and the like.

The invention relates to a preparation method of a hydroxy-terminated perfluoropolyether compound. Perfluoropolyether carboxylic acid or ester used as a raw material is subjected to reducing reaction to obtain the hydroxy-terminated perfluoropolyether compound, wherein hydrogen is used as the reducer of the reducing reaction, an activated carbon supported ruthenium or rhodium catalyst is used as the catalyst, and the reaction is carried out at 80-200 DEG C under the pressure of 10-50MPa. Compared with the prior art, the invention has the advantages of high reaction yield, simple after-treatment and fewer three wastes, and is simple to operate.

A method for the quantification of 227Ac in a 223Ra composition comprising passing the composition through a first solid phase extraction column A, wherein said column comprises a thorium specific resin, passing the eluate of column A through a second solid phase extraction column B, wherein said column comprises an actinium specific resin and recovering the 227Ac absorbed onto the resin in column B and determining the amount thereof.

Various embodiments disclosed relate to polymers and methods of making the same. In various embodiments, the present invention provides a method of forming a polymer including subjecting a composition including a carboxylic acid having the structure (Rf—O)z1—Ra to conditions sufficient to form a polymer having the structure Reg—[O—Ra(O—Rb)z1-2—O—C(O)—R′(O—Rd)z2-1—C(O)]n—O—Ra(O—Rb)z1-2—O—Reg or a salt or ester thereof, wherein Ra, R′ Rb, Rd, Rf, Reg, z1, z2, and n are as defined herein. In various embodiments, the polymer is a tackifier, a viscosifier, or a combination thereof.

The invention relates to a preparation method of S-(+)-o-chlorobenzoyl glycine, which comprises the following steps: firstly, o-chlorobenzaldehyde, potassium cyanide and ammonium carbonate are used as raw materials for synthesizing (plus or minus) o-chlorobenzoyl-hydantoin; and then agrobacterium is used as enzyme and the S-(+)-o-chlorobenzoyl-hydantoin is selectively hydrolyzed into S-(+)-o-chlorobenzoyl glycine, and R-(-)-o-chlorobenzoyl-hydantoin is self-racemized and hydrolyzed into S-(+)-o-chlorobenzoyl glycine. Compared with the traditional splitting method, no chiral compound is used in the production technique, chiral products are obtained directly through enzyme catalysis and splitting is not needed, therefore, the production technique has high yield, low cost and simplified technique; in addition, as the technology of enzyme catalysis is used, less organic solvent is used and less waste is produced in the whole production technical process, thus being beneficial to the environmental protection.

The invention discloses a preparation method for preparing an intermediate compound II of pregabalin. The preparation method of the intermediate compound II comprises the following steps of: (1) undergoing an SN2 substitution reaction on a compound VI and XCH2COOR2 to obtain a compound I; and (2) undergoing a Wittig-Hornor reaction on the compound I obtained in the step (1) and isobutylaldehyde, wherein R1 is alkoxyl with 1-6 carbon atoms or aryl with 6-10 carbon atoms; X is halogen; and R2 is alkyl with 1-6 carbon atoms. The invention further relates to a preparation method for preparing an intermediate compound V of pregabalin. The preparation method of the intermediate compound V comprises the following step of: undergoing an asymmetric hydrogenation reaction on the compound IV and hydrogen gas in a solvent under the action of [Rh((Sc,Rp)-Duanpos)(COD)]BF4, wherein M is H, alkyl with 1-6 carbon atoms or t-BuNH<3+>.

The invention provides a forming and shaping integrated production device for a mute bearing retainer. The forming and shaping integrated production device for the mute bearing retainer comprises a feeding assembly, a movement assembly, a forming and shaping integrated die and a punching die. The feeding assembly comprises a feeding hydraulic cylinder, a position fixing plate and a pushing plate. The movement assembly comprises a first transverse guide rod, a second transverse guide rod, a left longitudinal guide rod, a right longitudinal guide rod, a transverse reset spring and a longitudinal reset spring. The feeding assembly, the forming and shaping integrated die and the punching die are sequentially arranged between the left longitudinal guide rod and the right longitudinal guide rod. The forming and shaping integrated die comprises an integrated upper die and an integrated lower die. The punching die comprises an upper punching die body and a lower punching die body. The forming and shaping integrated production device for the mute bearing retainer is reasonable in structural design, automatic movement can be achieved when workpieces are machined, the machining accuracy is high, a few waste materials are generated, and using for production is facilitated.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a chiral dihydropyran ring derivative and a preparation method and application thereof. The chiral dihydropyran ring derivative has the structure shown in the formula (I), the derivative is novel in structure, has a good anti-tumor effect, has a good inhibition effect on human osteosarcoma cells, human colon cancer cells and human non-small cell lung cancer cells, and especially has an excellent inhibition effect on the human non-small cell lung cancer cells. The inhibition IC50 of the derivative can be as low as 7 [mu]M. The derivative has a great application value in the anti-tumor effect aspect, and is expected to be prepared into anti-tumor drugs or drugs for inhibiting tumor cell proliferation, especially drugs for resisting human osteosarcoma, human colon cancer and human non-small cell lung cancer. Meanwhile, the preparation method disclosed by the invention has the advantages of cheap and easily available raw materials, few reaction steps, simplicity and safety in operation, low cost, few generated wastes, high atom economy, high selectivity and high yield.

The present invention discloses a preparation method for optical activity active 3-amino butanol and optical activity 3-amino butyric acid. The optical activity active 3-amino butanol preparation method comprises: in a solvent, under effects of a hydroboration reduction agent and a Lewis acid, carrying out a reduction reaction on a compound represented by a formlu 65 to produce a compound represented by a formlu 14. The optical activity active 3-amino butyric acid preparation method comprises: carrying out a hydrolysis reaction on a compound represented by a formlu 64 to produce a compound represented by a formlu 65. According to the present invention, the preparation method has characteristics of cheap and easily-available raw materials, simple operation, short process route, no hazard of raw materials, high yield, little waste production, environment protection, high raw material conversion rate, high product chemical purity and high product optical purity, and the industrialization is easily achieved. The formulas 64, 65 and 14 are defined in the instruction.

The present disclosure relates to a method of synthesizing 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine (ceritinib) and / or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing ceritinib.

The invention provides an automatic shifting producing device for a silent bearing retainer. The device comprises a feeding assembly, a shifting assembly, a forming die, a shaping die and a punching die, wherein the feeding assembly comprises a feeding hydraulic cylinder, a position fixing plate and a pushing plate; the shifting assembly comprises a first transverse guide rod, a second transverse guide rod, a left longitudinal guide rod, a right longitudinal guide rod, a transverse returning spring and a longitudinal returning spring; the forming die comprises an upper forming die and a lower forming die; the shaping die comprises an upper shaping die and a lower shaping die; the punching die comprises an upper punching die and a lower punching die; the upper punching die comprises a punching propping plate, punching pins and a guide plate, wherein the punching pins are arranged as a circle; a plurality of guide holes through which the punching pins pass are formed in the guide plate; a circular clamping groove is formed in the bottom part of the guide plate; a circular supporting groove for storing the silent bearing retainer is formed in the top part of the lower punching die. The device is reasonable in structural design, enables automatic shifting of a workpiece in processing, is high in processing accuracy, produces few wastes, and is beneficial for production and application.

The invention discloses a preparation method for preparing an intermediate compound II of pregabalin. The preparation method of the intermediate compound II comprises the following steps of: (1) undergoing an SN2 substitution reaction on a compound VI and XCH2COOR2 to obtain a compound I; and (2) undergoing a Wittig-Hornor reaction on the compound I obtained in the step (1) and isobutylaldehyde, wherein R1 is alkoxyl with 1-6 carbon atoms or aryl with 6-10 carbon atoms; X is halogen; and R2 is alkyl with 1-6 carbon atoms. The invention further relates to a preparation method for preparing an intermediate compound V of pregabalin. The preparation method of the intermediate compound V comprises the following step of: undergoing an asymmetric hydrogenation reaction on the compound IV and hydrogen gas in a solvent under the action of [Rh((Sc,Rp)-Duanpos)(COD)]BF4, wherein M is H, alkyl with 1-6 carbon atoms or t-BuNH<3+>.

The invention discloses a method of preparing monobutyl tin trichloride and dibutyl tin dichloride from low purity tributyl tin chloride. The method comprises following steps: (1) mixing tributyl tinchloride with a purity lower than 95% with tin tetrachloride, controlling the temperature to carry out reactions to obtain a mixture composed of monobutyl tin trichloride and dibutyl tin dichloride; and (2) distilling and separating the mixture obtained in the step (1) to obtain monobutyl tin trichloride and dibutyl tin dichloride. Low purity and waste tributyl tin chloride is fully utilized to generate monobutyl tin trichloride and dibutyl tin dichloride that can be used, the cost for processing sewage of organic tin catalysts is reduced, and the utilization rate is improved.

The present invention relates to a 1-deoxynojirimycin enriched mulberry leaf preparation method and an obtained ultra-fine powder, which belongs to the processing field of medicinal and edible food. Fresh and complete tender mulberry leaves are washed, air-dried and cut into slice shapes with a length and width of 3-6 cm*3-6 cm, the mulberry leaf broken slices are soaked in a glucose solution at a temperature of 30-60 DEG C and a concentration of 10-30 g / L for 3-5 hours, the taken mulberry broken slices are dried to a water content to below 5%, the dried mulberry broken slices are crushed into an average particle size of 8 [mu]m or less, and the crushed mulberry leaves are dried to a water content to below 5%, thereby obtaining the 1-deoxynojirimycin enriched mulberry leaf ultra-fine powder. During the fresh mulberry leaf soaking process, endogenous DNJ synthesis related enzymes are activated and the glucose is catalyzed to enrich DNJ. The highest content of the finished product of the DNJ is 250mg / 100g. The obtained product by the method is clear in health-care function and safe and reliable in consumption.

Cosmetic article (1) for application to the eyelid, the eyelashes and / or the eyebrows, including:—at least one element (2) to be applied,—at least one adhesive layer (5) which is at least partially in contact with the element (2) to be applied, this adhesive layer (5) including at least one water-resistant adhesive material, and—at least one layer (6) for protecting the adhesive layer (5), externally covering same and including at least one water-soluble polymer.

The invention discloses a method for synthesizing a 1,2,3-triaryl-1-acetone compound from benzyl chloride through non-metal-catalyzed carbonylation. According to the method, carbon monoxide is taken as a carbonyl source, and an iodine catalyst is utilized for catalyzing carbonylation-alkylation domino reaction of benzyl chloride and an aryl boron reagent in medium polyethylene glycol in the presence of the iodine catalyst and alkali so as to directly prepare the 1,2,3-triaryl-1-acetone compound. In the method, noble metal catalysts and ligands are not used, and the reaction can be carried out under the normal pressure; and the method has the advantages that a substrate is wide in source, stable and low in cost, the catalyst is low in cost and easily available, little waste is produced, the application range is wide, the reaction selectivity is high, and the yield of the target product is high.

The invention belongs to the technical field of medicinal chemistry, and specifically relates to a multi-substituted naphthoquinone derivative and its preparation method and application. The structure of the derivative is shown in the general formula (I), wherein, R 1 selected from ethoxy, diphenylmethoxy, linalyl, D-menthol; R 2 selected from thiophene, phenyl, p-bromophenyl, p-methoxyphenyl, 2,4,6-trimethylphenyl; R 3 selected from hydrogen, nitro; R 4 Selected from hydrogen, fluorine, and bromine; the derivative has a novel structure and has a good antitumor effect, especially has a good inhibitory effect on colorectal adenocarcinoma cells, osteosarcoma cells and breast cancer cells. It has great application value and is expected to be prepared as an antitumor drug; at the same time, the preparation method of the polysubstituted naphthoquinone derivative has fewer reaction steps, simple and safe operation, low cost, less waste generation, high atom economy, and high selectivity. Sex, the advantage of high yield.

A method for recovering NiSO4.6H2O crystals from a nickel rich organic phase is provided. The method includes contacting a nickel rich organic phase with an aqueous strip solution of sufficient H2SO4 concentration to extract nickel from the organic phase and of sufficient Ni2+ concentration to precipitate NiSO4.6H2O crystals and form a nickel lean organic phase. Also provided are methods for recovering NiSO4.6H2O crystals that include preceding processing steps, including low temperature pressure oxidation (LTPOX) autoclaving of a nickel sulphide concentrate to afford a pregnant leach solution (PLS).

The invention provides an automatic shifting producing device for a silent bearing retainer. The device comprises a feeding assembly, a shifting assembly, a forming die, a shaping die and a punching die, wherein the feeding assembly comprises a feeding hydraulic cylinder, a position fixing plate and a pushing plate; the shifting assembly comprises a first transverse guide rod, a second transverse guide rod, a left longitudinal guide rod, a right longitudinal guide rod, a transverse returning spring and a longitudinal returning spring; the forming die comprises an upper forming die and a lower forming die; the shaping die comprises an upper shaping die and a lower shaping die; the punching die comprises an upper punching die and a lower punching die; the upper punching die comprises a punching propping plate, punching pins and a guide plate, wherein the punching pins are arranged as a circle; a plurality of guide holes through which the punching pins pass are formed in the guide plate; a circular clamping groove is formed in the bottom part of the guide plate; a circular supporting groove for storing the silent bearing retainer is formed in the top part of the lower punching die. The device is reasonable in structural design, enables automatic shifting of a workpiece in processing, is high in processing accuracy, produces few wastes, and is beneficial for production and application.

In the present invention, a hydroxyl group substitution product is manufactured by reaction of an alcohol with sulfuryl fluoride (SO2F2) in the presence of an organic base and a nucleophile (X−). The present invention is thus effective as an industrial manufacturing method that uses a relatively cheap reagent suitable for large-scale applications and can be accomplished in a simple process with easy purification operation and less waste generation and is suitably applicable for manufacturing of optically active hydroxyl group substitution products, notably optically active α-hydroxyl group substitution ester and optically active 4-hydroxyl group substitution proline. The manufacturing method of the present invention solves all of the prior art problems and can be applied for industrial uses.

The invention relates to a preparation method of a hydroxy-terminated perfluoropolyether compound. Perfluoropolyether carboxylic acid or ester used as a raw material is subjected to reducing reaction to obtain the hydroxy-terminated perfluoropolyether compound, wherein hydrogen is used as the reducer of the reducing reaction, an activated carbon supported ruthenium or rhodium catalyst is used as the catalyst, and the reaction is carried out at 80-200 DEG C under the pressure of 10-50MPa. Compared with the prior art, the invention has the advantages of high reaction yield, simple after-treatment and fewer three wastes, and is simple to operate.

Provided is a method for producing a compound using a biocatalyst. In the method for continuously producing a compound using a biocatalyst in one or a plurality of reaction tanks, the downstream reaction temperature is set higher than the upstream reaction temperature of the flow of the catalyst in a reaction tank or between reaction tanks.

The invention provides a forming and shaping integrated production device for a mute bearing retainer. The forming and shaping integrated production device for the mute bearing retainer comprises a feeding assembly, a movement assembly, a forming and shaping integrated die and a punching die. The feeding assembly comprises a feeding hydraulic cylinder, a position fixing plate and a pushing plate. The movement assembly comprises a first transverse guide rod, a second transverse guide rod, a left longitudinal guide rod, a right longitudinal guide rod, a transverse reset spring and a longitudinal reset spring. The feeding assembly, the forming and shaping integrated die and the punching die are sequentially arranged between the left longitudinal guide rod and the right longitudinal guide rod. The forming and shaping integrated die comprises an integrated upper die and an integrated lower die. The punching die comprises an upper punching die body and a lower punching die body. The forming and shaping integrated production device for the mute bearing retainer is reasonable in structural design, automatic movement can be achieved when workpieces are machined, the machining accuracy is high, a few waste materials are generated, and using for production is facilitated.

The present invention belongs to the technical field of medicinal chemistry, and specifically relates to an indenone imine derivative and its preparation method and application. The structure of the indenone imine derivative is shown in the general formula (I), wherein the R 1 selected from hydrogen, fluorine, chlorine, bromine; R 2 Selected from hydrogen, fluorine, chlorine, trifluoromethyl, and methoxycarbonyl; the derivative has a novel structure and has good antitumor effects, especially for colorectal adenocarcinoma cells, osteosarcoma cells, and breast cancer cells Inhibition of anti-tumor effect has great application value, and it is expected to be prepared as anti-tumor drug, especially anti-colorectal cancer cell, osteosarcoma cell and breast cancer cell drug; meanwhile, the indenone imine The preparation method of the derivative has fewer reaction steps, simple and safe operation, low cost, less waste generation, and has the advantages of high atom economy and high yield.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to indanone imine derivatives and a preparation method and application thereof. The structures of the indanone imine derivatives are as shown in a general formula (I) which is described in the specification. In the general formula (I), R1 is selected from hydrogen, fluorine, chlorine and bromine; and R2 is selected from hydrogen, fluorine, chlorine, a trifluoromethyl group and a methoxycarbonyl group. The derivatives are novel in structure, have very good anti-tumor effects, particularly show a very good inhibition effect on colorectal adenocarcinoma cells, osteosarcoma cells and breast cancer cells, have a very great application value in the aspect of the anti-tumor effect, and are expected to be made into anti-tumor drugs, especially drugs for resisting colorectal cancer cells, osteosarcoma cells and breast cancer cells; and meanwhile, the preparation method of the indanone imine derivatives has the advantages of few reaction steps, simplicity and safety in operation, low cost, less generated waste, high atom economy and high yield.