30results about How to "Generate less waste" patented technology

The present invention discloses a preparation method for optical activity active 3-amino butanol and optical activity 3-amino butyric acid. The optical activity active 3-amino butanol preparation method comprises: in a solvent, under effects of a hydroboration reduction agent and a Lewis acid, carrying out a reduction reaction on a compound represented by a formlu 65 to produce a compound represented by a formlu 14. The optical activity active 3-amino butyric acid preparation method comprises: carrying out a hydrolysis reaction on a compound represented by a formlu 64 to produce a compound represented by a formlu 65. According to the present invention, the preparation method has characteristics of cheap and easily-available raw materials, simple operation, short process route, no hazard of raw materials, high yield, little waste production, environment protection, high raw material conversion rate, high product chemical purity and high product optical purity, and the industrialization is easily achieved. The formulas 64, 65 and 14 are defined in the instruction.

A wristband is assembled from a flexible preferably vinyl carrier and a preferably laminated ID label, the carrier having a panel portion and a strap portion with a snap closure located in a toe extension at the end of the carrier adjacent the panel. The strap has a series of holes, one of which is captured within the snap closure to attach the wristband to the wearer's limb. The laminated ID label has a pair of opposing slots, one of which slips over the strap to abut the panel and the other of which is captured by the snap closure to attach the label to the carrier. The panel portion has a relieved edge formed along its opposing sides which increases the comfort of the wristband as it is worn.

The invention relates to a preparation method of a hydroxy-terminated perfluoropolyether compound. Perfluoropolyether carboxylic acid or ester used as a raw material is subjected to reducing reaction to obtain the hydroxy-terminated perfluoropolyether compound, wherein hydrogen is used as the reducer of the reducing reaction, an activated carbon supported ruthenium or rhodium catalyst is used as the catalyst, and the reaction is carried out at 80-200 DEG C under the pressure of 10-50MPa. Compared with the prior art, the invention has the advantages of high reaction yield, simple after-treatment and fewer three wastes, and is simple to operate.

A method for the quantification of ²²⁷Ac in a ²²³Ra composition comprising passing the composition through a first solid phase extraction column A, wherein said column comprises a thorium specific resin, passing the eluate of column A through a second solid phase extraction column B, wherein said column comprises an actinium specific resin and recovering the ²²⁷Ac absorbed onto the resin in column B and determining the amount thereof.

Various embodiments disclosed relate to polymers and methods of making the same. In various embodiments, the present invention provides a method of forming a polymer including subjecting a composition including a carboxylic acid having the structure (R^f—O)_z1—R^a to conditions sufficient to form a polymer having the structure R^eg—[O—R^a(O—R^b)_z1-2—O—C(O)—R′(O—R^d)_z2-1—C(O)]_n—O—R^a(O—R^b)_z1-2—O—R^eg or a salt or ester thereof, wherein R^a, R′ R^b, R^d, R^f, R^eg, z1, z2, and n are as defined herein. In various embodiments, the polymer is a tackifier, a viscosifier, or a combination thereof.

The invention discloses a preparation method for preparing an intermediate compound II of pregabalin. The preparation method of the intermediate compound II comprises the following steps of: (1) undergoing an SN2 substitution reaction on a compound VI and XCH2COOR2 to obtain a compound I; and (2) undergoing a Wittig-Hornor reaction on the compound I obtained in the step (1) and isobutylaldehyde, wherein R1 is alkoxyl with 1-6 carbon atoms or aryl with 6-10 carbon atoms; X is halogen; and R2 is alkyl with 1-6 carbon atoms. The invention further relates to a preparation method for preparing an intermediate compound V of pregabalin. The preparation method of the intermediate compound V comprises the following step of: undergoing an asymmetric hydrogenation reaction on the compound IV and hydrogen gas in a solvent under the action of [Rh((Sc,Rp)-Duanpos)(COD)]BF4, wherein M is H, alkyl with 1-6 carbon atoms or t-BuNH<3+>.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a chiral dihydropyran ring derivative and a preparation method and application thereof. The chiral dihydropyran ring derivative has the structure shown in the formula (I), the derivative is novel in structure, has a good anti-tumor effect, has a good inhibition effect on human osteosarcoma cells, human colon cancer cells and human non-small cell lung cancer cells, and especially has an excellent inhibition effect on the human non-small cell lung cancer cells. The inhibition IC50 of the derivative can be as low as 7 [mu]M. The derivative has a great application value in the anti-tumor effect aspect, and is expected to be prepared into anti-tumor drugs or drugs for inhibiting tumor cell proliferation, especially drugs for resisting human osteosarcoma, human colon cancer and human non-small cell lung cancer. Meanwhile, the preparation method disclosed by the invention has the advantages of cheap and easily available raw materials, few reaction steps, simplicity and safety in operation, low cost, few generated wastes, high atom economy, high selectivity and high yield.

Cosmetic article (1) for application to the eyelid, the eyelashes and/or the eyebrows, including:—at least one element (2) to be applied,—at least one adhesive layer (5) which is at least partially in contact with the element (2) to be applied, this adhesive layer (5) including at least one water-resistant adhesive material, and—at least one layer (6) for protecting the adhesive layer (5), externally covering same and including at least one water-soluble polymer.

The invention discloses a method for synthesizing 1,2,3-triaryl-1-acetone compound by metal-free catalytic carbonylation of benzyl chloride. In the medium polyethylene glycol, under the action of iodide catalyst and alkali, carbon monoxide is A carbonyl source and an iodine catalyst catalyze the carbonylation-alkylation domino reaction of benzyl chloride and aryl boron reagents to directly prepare 1,2,3-triaryl-1-acetone compounds. The method for preparing 1,2,3-triaryl-1-acetone compounds of the present invention does not require noble metal catalysts and ligands, and can react under normal pressure, and has wide, stable and cheap sources of substrates; the catalyst is cheap and easy to obtain; It has the advantages of less waste, wide application range, high reaction selectivity and high yield of target product.

A method for recovering NiSO₄.6H₂O crystals from a nickel rich organic phase is provided. The method includes contacting a nickel rich organic phase with an aqueous strip solution of sufficient H₂SO₄ concentration to extract nickel from the organic phase and of sufficient Ni²⁺ concentration to precipitate NiSO₄.6H₂O crystals and form a nickel lean organic phase. Also provided are methods for recovering NiSO₄.6H₂O crystals that include preceding processing steps, including low temperature pressure oxidation (LTPOX) autoclaving of a nickel sulphide concentrate to afford a pregnant leach solution (PLS).

In the present invention, a hydroxyl group substitution product is manufactured by reaction of an alcohol with sulfuryl fluoride (SO₂F₂) in the presence of an organic base and a nucleophile (X⁻). The present invention is thus effective as an industrial manufacturing method that uses a relatively cheap reagent suitable for large-scale applications and can be accomplished in a simple process with easy purification operation and less waste generation and is suitably applicable for manufacturing of optically active hydroxyl group substitution products, notably optically active α-hydroxyl group substitution ester and optically active 4-hydroxyl group substitution proline. The manufacturing method of the present invention solves all of the prior art problems and can be applied for industrial uses.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to indanone imine derivatives and a preparation method and application thereof. The structures of the indanone imine derivatives are as shown in a general formula (I) which is described in the specification. In the general formula (I), R1 is selected from hydrogen, fluorine, chlorine and bromine; and R2 is selected from hydrogen, fluorine, chlorine, a trifluoromethyl group and a methoxycarbonyl group. The derivatives are novel in structure, have very good anti-tumor effects, particularly show a very good inhibition effect on colorectal adenocarcinoma cells, osteosarcoma cells and breast cancer cells, have a very great application value in the aspect of the anti-tumor effect, and are expected to be made into anti-tumor drugs, especially drugs for resisting colorectal cancer cells, osteosarcoma cells and breast cancer cells; and meanwhile, the preparation method of the indanone imine derivatives has the advantages of few reaction steps, simplicity and safety in operation, low cost, less generated waste, high atom economy and high yield.