The invention discloses a high-temperature-resistant, high-toughness and sulfuration-resistant AMOLED packaging silica gel prepared from the following raw materials in parts by weight: 35-44 parts ofhydrogen-terminated silicone resin, 26-32 parts of vinyl resin, 15-26 parts of polymethylphenylsiloxane, 7-11 parts of dimethyl polysiloxane monomers, 7-14 parts of divinyltetramethyldisiloxane, 6-12parts of tetrabutyl ammonium hydroxide, 3-6 parts of catalyst, 4-7 parts of binder, 3-5 parts of crosslinking agent, 2-4 parts of inhibitor, 2-3 parts of curing accelerator and 3-5 parts of curing inhibitor. Compared with the prior art, the high-temperature-resistant, high-toughness and sulfuration-resistant AMOLED packaging silica gel has the beneficial effects that the AMOLED packaging silica gel is strong in sulfuration resistance, good in sealing performance and high temperature resistance, good in weather resistance, yellowing-resistant and easy to defoam and further has the advantages such as high toughness and convenience in operation in addition to excellent optical structure and high refractive index.