The invention discloses a worm self-locking anti-loose type overload protective clamp, and belongs to the field of clamps. The worm self-locking anti-loose type overload protective clamp comprises a clamp base, a left fixing block, a left screw, a left clamping block, a right clamping block, a right screw and a right fixing block, a dovetail groove is formed in the clamp base, and the left fixing block and the right fixing block are arranged at the two ends of the dovetail groove. The worm self-locking anti-loose type overload protective clamp further comprises a safe engaging and disengaging mechanism, a fixed base, an adjusting rod, an outer ring, a screw, a spring, a steel ball, a square shank and worm self-locking anti-loose devices, both the adjusting rod and the left screw are provided with the worm self-locking anti-loose devices, the adjusting rod is assembled in a threaded hole of the fixed base, the square shank is connected with the adjusting rod, the screw is assembled in a threaded hole of the outer ring, the steel ball is pressed on the surface of the square shank, and the spring is arranged between the screw and the steel ball. The worm self-locking anti-loose type overload protective clamp solves the problems that an existing clamp is not easy to control in clamping force and prone to loosening, and has the advantages of being simple in structure, reasonable in design and easy to manufacture.