The invention discloses bream feed capable of improving disease resistance. The bream feed is prepared from components as follows: corn flour, soybean dregs, black bean powder, wheat middling, a nutrient enhancer, an attractant, a disease resistant agent and table salt, wherein the disease resistant agent is prepared from raw materials in parts by weight as follows: 3-5 parts of radix sophorae flavescentis, 1-3 parts of eupatorium adenophorum, 1-3 parts of green tea, 5-10 parts of fermented bread, 10-20 parts of wort, 1-3 parts of aquilegia viridiflora, 1-3 parts of lyonia leaves, 1-3 parts ofherba corydalis, 1-3 parts of gnaphalium affine, 10-15 parts of distillers' grains, 10-20 parts of milk, 10-20 parts of butter, 2-5 parts of chicken paste, a microbial agent and an enzymatic preparation; the microbial agent is prepared from raw materials as follows: Raman lactobacillus, gram-positive vacilli, bacillus mucilaginosus, actinomycetes and saccharomycetes; the enzymatic preparation comprises bromelin and amyloglucosidase. The bream feed has the benefits of improving disease resistance of bream, increasing the survival rate, promoting bream weight increase and improving the bream quality.