The invention provides a portable small-flow precise pressure regulating device. The portable small-flow precise pressure regulating device comprises an upper shell assembly, a precise pressure regulating assembly and a lower shell assembly. The upper shell assembly comprises a screw, an upper shell and a screw connecting part. The precise pressure regulating assembly comprises a first spring, aninner liner, a positioning base, a lower spring, a third gasket, a diaphragm, a limiting ring, an outer liner, a check block, an upper spring, an upper valve and a lower valve. The lower shell assembly comprises a lower shell, a first filler neck, a nut, a nozzle, a first gasket, a second filler neck and a second gasket. Precise pressure regulating of multiple media under different working conditions is achieved, and the portable small-flow precise pressure regulating device has the beneficial effects that the structure is relatively simple, output pressure is stable, and regulating is precise.