The invention relates to a technological method of a clamping device of a multi-position cross-shaft processing machine, by adopting the cross-shaft V-shaped slot positioning technology, milling and drilling tools are mounted on four rotating main shafts, the rotating main shafts are fixed on a workbench which can move left, right, frontward and backward, by utilizing the movement of the rotatingmain shafts, four end surfaces of the cross-shaft are firstly simultaneously milled, then the workbench is automatically returned onto a central line of the V-shaped slot, the four main shafts are simultaneously near to the cross-shaft, and four central holes are drilled on the cross-shaft at one time, thereby completing the processing of the end surfaces of the cross-shaft and the central holes on one working procedure at one time. The technological process comprises the following steps of: sawing-forging-milling-drilling-turning a shaft neck-thermal treatment-shot blasting-grinding the shaftneck-defect detection-inspection-packaging and warehousing, thereby not only reducing the processing working procedure of the cross-shaft, reducing the work time and the cost, reducing the labor intensity, improving the processing working efficiency by nearly 10 times, and saving the energy consumption by more than 60%, but also ensuring the concentricity and the vertical degree of the cross-shaft, realizing high processing precision and high qualified rate of the cross-shaft product.