A high-efficiency high-pressure horizontal multi-stage centrifugal pump, related to the technical field of centrifugal pumps, including a suction section, a middle section, a guide vane, an impeller, a pump shaft, a water-lubricated bearing, an outlet section, an axial force balance mechanism and a seal, etc., and is characterized in that The suction port of the pump is different from the radial arrangement of all previous horizontal multistage pumps, but is arranged in the axial direction, which greatly improves the hydraulic efficiency of the first stage impeller and the cavitation performance of the pump; , the liquid lubricated shaft is installed inside the hydraulic part; the sliding bearing near the outlet section also acts as a balance hub for balancing the axial force, and together with the balance plate constitutes an automatic axial force balancing mechanism; the pump uses an internal liquid sliding bearing, only One shaft extension, compact structure, only one set of seals. It has the advantages of less friction pairs, high efficiency, good reliability, less wearing parts, and easy disassembly and assembly. The present invention is suitable for all occasions of conveying cleaning liquid.