33results about How to "Reflect the effect of green environmental protection" patented technology

The invention relates to a three-in-one spunlaced composite non-woven fabric, belonging to the technical field of non-woven fabrics, wherein the non-woven fabric comprises a substrate layer, a hygroscopic layer and a hydrophilic layer, which are integrated in spunlace, wherein the hygroscopic layer is located between the substrate layer and the hydrophilic layer; the substrate layer comprises chemical short fibers or degradable short fibers; the hygroscopic layer comprises wood pulp short fibers; and the hydrophilic layer comprises spunbonded non-woven fabrics. The three-in-one spunlaced composite non-woven fabric has the advantages that the non-woven fabric has good softness, excellent contact feel and great water aggregation performance as the chemical short fibers or degradable short fibers are used as the substrate layer, not only has excellent strength but also has great water aggregation performance as the spunbonded non-woven fabrics are used as the hydrophilic layer, and can play a good high-hygroscopic effect as the wood pulp short fibers are used as the hygroscopic layer; both the hygroscopic layer and the hydrophilic layer are degradable to reflect the green environmental effect; and the overall structure is simple and inexpensive to meet the disposable requirement.

The invention discloses a method for preparing alectinib. The method comprises the following steps: firstly, by taking 6-bromine-7-methoxy-3,4-dihydro-2-naphthalenone as a raw material, performing hydrolysis so as to obtain methoxyl, performing deprotection, further performing trifluoromethanesulfonic acid esterification reaction on trifluoromethanesulfonic anhydride so as to obtain a trifluoromethanesulfonie ester compound, performing bimethylation reaction, performing substitution reaction on 1,1-dimethyl-6-bromine-2-oxo-3,4-dihydro-7-trifluoromethanesulfonate and another raw material, namely 4-(4-piperidyl) morpholine, implementing a classical reaction Fisher indole synthesis method, performing cyclization on carbonyl and phenylhydrazine under acid catalysis so as to form indole parent nucleus, and finally performing oxidation reaction, boric acid formation and catalytic coupling reaction, thereby obtaining the alectinib. The method is simple to operate and relatively low in cost, is a green and environmental-friendly process method, and is applicable to industrial production.

The invention discloses a lenvatinib synthesizing method.The method includes the steps that 4-amino-3-chlorophenol and benzyl chloroformate are subjected to amidation reaction, the obtained 4-(carbobenzoxy)amino-3-chlorophenol and 4-chlorine-7-methoxyquinoline-6-formamide are subjected to condensation reaction, the obtained 4-[3-chlorine-4-(carbobenzoxy)aminophenoxy]-7-methoxyquinoline-6-formamide and cyclopropylamine are subjected to amidation reaction, and the finished product lenvatinib is obtained.The method is short in process route step, operation is simplified, cost is low, and the method is environmentally friendly and suitable for industrial production.

The invention discloses a preparation method of alectinib. The preparation method comprises the following steps of using 2-(4-bromo-3-hydroxyphenyl)ethyl acetate as a raw material; performing trifluoromethanesulfonic acid etherification with trifluoromethyl sulfonic anhydride, so as to obtain a trifluoromethanesulfonic acid etherification compound; performing substitution reaction with the other raw material, namely 4-(4-piperidyl)morpholine, so as to obtain 2-{4-bromo-3-[4-morpholine-4-yl]piperidine-1-yl]phenyl}ethyl acetate, then performing dimethylation reaction and hydrolysis reaction to obtain 2-{4-bromo-3-[4-morpholine-4-yl]piperidine-1-yl]phenyl}-2-methyl propionate to be subjected to condensation reaction with malonic acid mono-tert-butyl ester, so as to obtain the 4-{4-bromo-3-[4-morpholine-4-yl]piperidine-1-yl]phenyl}-4-methyl-3-oxopentanoate tert-butyl; utilizing a typical Fischer indole synthesis method, enabling carbonyl and phenylhydrazine to cyclize under the acid catalyzing action to form indole nuclear parent; finally, performing cyclizing reaction, boric acidifying and catalytic coupling reaction, so as to prepare the alectinib. The preparation method has the advantages that the design of route method is reasonable, the price of raw material is low, the obtaining is easy, and the reaction condition is easily and effectively controlled.

The invention discloses a preparation method of Alectinib. The method comprises the steps that tert-butyl 4-(4-ethyl-3-iodophenyl)-4-methyl-3-oxopentanoate and 4-(piperidin-4-yl)-morpholine are subjected to a substitution reaction; obtained tert-butyl 4-{4-ethyl-3-[4-(morpholine-4-yl)piperidin-1-yl]phenyl}-4-methyl-3-oxopentanoate is subjected to a cyclization reaction and hydrolysis reaction, obtained 6-cyano-2-{2-[4-ethyl-3-(4- morpholine-4-yl)piperidin-1-yl)phenyl]prop-2-yl}-1H-indole-3-carboxylic acid is subjected to the cyclization reaction, and the Alectinib is obtained. According to the method, the operation is simplified, the cost is low, and the method is an environment-friendly technical method and suitable for industrial production.

The invention provides a preparation method of an R-lipoic acid cholinesterase halide and belongs to the technical field of medicinal chemical synthesis. R-lipoic acid-2-halogen ethyl ester I and trimethylamine react in a solvent to generate quaternary ammonium salt, so that an R-lipoic acid cholinesterase halide II is obtained. Impurities during reaction are fewer, and operations such as aftertreatment and purification are simplified; raw materials and the used reagent are easy to get and safe to use, and a reaction route is reasonable, so that the preparation method is applicable to industrial enlarged production; and no pollutant is produced in a preparation process, so that the green environmental protection effect is realized.

The invention discloses a preparation method of an Alectinib intermediate, namely tert-butyl 4-{4-ethyl-3-[4-(morpholine-4-yl)piperidin-1-yl]phenyl}-4-methyl-3-oxopentanoate. The method comprises the steps that ethyl 2-(4-ethyl-3-methoxyphenyl)acetate and iodomethane are subjected to a bis-methylation reaction; obtained ethyl 2-(4-ethyl-3-methoxyphenyl)-2-methylpropanoate is subjected to a hydrolysis reaction; obtained ethyl 2-(4-ethyl-3-hydroxyphenyl) -2-methylpropanoate is subjected to a trifluoromethanesulfonic acid esterification reaction; obtained 5-[2-( ethyloxylcarbonyl)prop-2-yl]-2-ethylphenyl trifluoromethanesulfonate is subjected to a substitution reaction; obtained ethyl 2-{4-ethyl-3-[4-(morpholine-4-yl)piperidin-1-yl] phenyl} -2-methylpropanoate is subjected to a hydrolysis reaction; obtained 2-{4-ethyl-3-[4-(morpholine-4-yl)piperidin-1-yl] phenyl}-2-methyl propioric acid is subjected to a condensation reaction to obtain the Alectinib intermediate. According to the method, the operation is simplified, the cost is low, and the method is an environment-friendly technical method and suitable for industrial production.

The invention relates to a preparation method for apatinib. The preparation method comprises the following steps: performing condensation reaction on 4-(tert-butoxycarbonyl group) alkyl phenylacetateand 1,4-butane dihalide, thereby acquiring 1-[4-(tert-butoxycarbonyl group) phenyl] alkyl cyclopentane formate; performing deprotection reaction on the acquired product, thereby acquiring 1-(4-aminophenyl) alkyl cyclopentane formate; performing amidation reaction on the acquired product and 2-chloronicotinoyl chloride, thereby acquiring 1-{4-[(2-chlorine pyridine-3-group) carbonyl amino] phenyl} alkyl cyclopentane formate; performing substitution reaction on the acquired product and 4-aminomethyl pyridine, thereby acquiring 1-{4-[(2-((4-pyridyl methyl) amino) pyridine-3-group) carbonyl amino]phenyl} alkyl cyclopentane formate; performing amidation reaction on the acquired product, thereby acquiring 1-{4-[(2-((4-pyridyl methyl) amino) pyridine-3-group) carbonyl amino] phenyl} cyclopentaneformamide; lastly, dehydrating, thereby acquiring an end product.

The invention discloses a preparation method of 1,1-dimethyl-6-ethyl-7-[4-(morpholine-4-yl)piperidine-1-yl]-3,4-dihydro-2-naphthalenone which is an alectinib intermediate. The method comprises: carrying out a bromination reaction between 6-ethyl-3,4-dihydro-2-naphthalenone and a bromination reagent; allowing the obtained 6-ethyl-7-bromine-3,4-dihydro-2-naphthalenone and 4-(4-piperidyl)morpholine to undergo a substitution reaction; and allowing obtained 6-ethyl-7-[4-(morpholine-4-yl)piperidine-1-yl]-3,4-dihydro-2-naphthalenone and iodomethane to undergo a dimethylation reaction to obtain 1,1-dimethyl-6-ethyl-7-[4-(morpholine-4-yl)piperidine-1-yl]-3,4-dihydro-2-naphthalenone. The preparation method is relatively short in steps, simplified in operation, and low is cost, is a green eco-friendly technical method, and is suitable for industrial production.

The invention discloses a synthesizing method for binimetinib. The method comprises the steps that 2,3,4-trifluoro-5-nitrobenzoic acid and O-(2-tert-butoxy ethyl)hydroxylamine are subjected to a condensation reaction, and obtained N-(2-tert-butoxy ethyoxyl)-2,3,4-trifluoro-5-nitrobenzamide and ammonium hydroxide are subjected to an ammonolysis reaction; obtained N-(2-tert-butoxy ethyoxyl)-2,4-diamino-3-fluoro-5-nitrobenzamide and formic acid are subjected to a ring-closure reaction in a Pearlman's catalyst; obtained N-(2-tert-butoxy ethyoxyl)-6-amino-7-fluoro-3H-benzimidazole-5-formamide and 4-bromo-2-fluoro-1-iodobenzene are subjected to a substitution reaction; obtained N-(2-tert-butoxy ethyoxyl)-6-[(4-bromo-2-fluoro-phenyl)amino]-7-fluoro-3H-benzimidazole-5-formamide is firstly subjected to a methylation reaction with methyl iodide and then subjected to a deprotection reaction with phosphoric acid, and binimetinib is obtained. The synthesizing method is short in route, operation is simplified, cost is low, and the synthesizing method is environmentally friendly and suitable for industrial production.

The invention provides a medium-voltage water-tree-retardant crosslinked polyethylene cable material and a preparation method thereof and belongs to the technical field of wire cable materials and preparation of the wire cable materials. The medium-voltage water-tree-retardant crosslinked polyethylene cable material is prepared from raw materials as follows: 60-75 parts of polyolefin composite resin, 15-25 parts of a polyethylene silane-grafting material, 5-10 parts of water-tree-retardant composite catalytic master batch and 2-5 parts of a cross-linking agent. The polyolefin composite resin comprises raw materials as follows: 60-80 parts of low-density polyethylene and 20-40 parts of ethylene vinyl acetate copolymer; the water-tree-retardant composite catalytic master batch comprises raw materials as follows: 70-80 parts of low-density polyethylene, 3-5 parts of a catalyst, 10-15 parts of a nucleating agent, 2-5 parts of an antioxidant, 0.1-0.2 parts of a crosslinking agent and 3-5 parts of an assistant crosslinking agent. Formation of a water tree is delayed, surrounding water can be dispersed to a certain extent, formation of the water tree can be effectively inhibited, the overall physical property of the material is improved, and the material has excellent mechanical and physical properties and is environment-friendly.

The invention discloses a method for synthesizing a fondaparinux sodium monosaccharide intermediate. According to the method, a fondaparinux sodium monosaccharide fragment intermediate, namely 1,6-dehydro-3-O-benzyl-beta-L-idopyranose, is prepared by taking 1,2-O-isopropylidene-3-O-benzyl-alpha-D-glucofuranose as a raw material, subjecting the raw material to an esterification reaction with benzoic acid, subjecting the reaction product to the esterification reaction with substituted sulfonic anhydride and/or substituted sulfonyl chloride, then subjecting the reaction product to a hydrolysis reaction, and adding a sulfuric acid aqueous solution for a reaction. The synthesis method has the advantages of simple process, few side reaction impurities and high yield, and is suitable for amplification synthesis process to meet the industrial production of fondaparinux sodium.