The invention relates to a gas-liquid-solid multi-phase mixing device for a fermentation tank, in particular to a coaxial double-blade submersible mixer for a large fermentation tank. The coaxial double-blade submersible mixer comprises a submersible motor, an inner rotating shaft, an outer rotating shaft, a first bevel gear, a second bevel gear and two groups of blades of which the installation directions are opposite; the first bevel gear and the second bevel gear are arranged in the submersible motor and driven by a rotor arranged in the submersible motor to synchronously rotate, the outer rotating shaft is installed on the submersible motor, the end, located in the submersible motor, of the outer rotating shaft is fixedly connected with the second bevel gear, the end, located outside the submersible motor, of the outer rotating shaft is fixedly connected with the first groups of blades, the inner rotating shaft is arranged in the outer rotating shaft, one end of the inner rotating shaft stretches out of the outer rotating shaft and penetrates through the second bevel gear to be fixedly connected with the first bevel gear, and the other end of the inner rotating shaft stretches out of the outer rotating shaft to be fixedly connected with the second groups of blades. According to the coaxial double-blade submersible mixer, coaxial opposite-blade mixing can be achieved, and the mixing and stirring effects achieved in the large fermentation tank are greatly improved.