The invention provides equipment for generating smoke with high-pressure high-speed air flow instead of a high temperature. The equipment comprises a high-pressure air source, an air source control device, an air source tee, an air feeding pipe, an air feeding quick coupling, a pressing sealing container, a flow control device, an air liquid mixing tee, a high-pressure air pipe, a mixing pipe and an atomizing spray nozzle. The high-pressure air source is connected with the air source control device, the air source control device, the air feeding pipe and the high-pressure air pipe are connected with the air source tee correspondingly, the air feeding pipe is fixedly connected with the pressure sealing container through the air feeding quick coupling, the flow control device is installed below the pressure sealing container, the flow control device, the high-pressure air pipe and the mixing pipe are connected with the air liquid mixing tee correspondingly, and the mixing pipe is connected with the atomizing spray nozzle. The high-pressure high-speed air flow is utilized, disinfection liquid is made to form a plenty of thin smoke rapidly and efficiently, and the equipment is suitable for being used for sterilization, disinfection and peculiar smell removal of rooms in a residence, hotel rooms, singing halls, dance halls, hospital wards, small warehouses, classrooms and other places where ventilation and illumination of sunlight are poor.