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42 results about "Interferome" patented technology

Interferome is an online bioinformatics database of interferon-regulated genes (IRGs). These Interferon Regulated Genes are also known as Interferon Stimulated Genes (ISGs). The database contains information on type I (IFN alpha, beta), type II (IFN gamma) and type III (IFN lambda) regulated genes and is regularly updated. It is used by the interferon and cytokine research community both as an analysis tool and an information resource. Interferons were identified as antiviral proteins more than 50 years ago. However, their involvement in immunomodulation, cell proliferation, inflammation and other homeostatic processes has been since identified. These cytokines are used as therapeutics in many diseases such as chronic viral infections, cancer and multiple sclerosis. These interferons regulate the transcription of approximately 2000 genes in an interferon subtype, dose, cell type and stimulus dependent manner. This database of interferon regulated genes is an attempt at integrating information from high-throughput experiments and molecular biology databases to gain a detailed understanding of interferon biology.

System and method for measuring phase

Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
Owner:MASSACHUSETTS INST OF TECH

Signal processing method for heterodyne interferometer

InactiveCN102230826AHigh dynamic measurement resolutionOptical measurementsPhase differenceHeterodyne interferometer
The invention discloses a signal processing method for a heterodyne interferometer. The method comprises the following steps of: providing a Span3-series XC3S1500 chip for an FPGA (Field Programmable Gate Array), chopping a reference signal and a measurement signal through a high-frequency small-power Schottky diode respectively to obtain positive half period signals and connecting with a pin of the FPGA; countering two paths of signals respectively at the counting period of 100 mum s and latching every 100 mum s, wherein the phase difference of the entire period is N1-N2; setting a count value of an initial phase difference in a first sampling counting period as n1 and latching by taking a reference signal as a standard, setting a count value of a tail end phase difference as n2, and setting a count value of a non-period phase different as n2-n1; setting a count value of an ith non-period phase difference as ni+1-n1; performing pulse filling counting on one period of the reference signal to obtain a count value NTr of the reference signal in the entire period; setting the phase difference in the sampling period as (N1-N2)+(ni+1-n1)/NTr; and obtaining measured displacement: L=lambda/2[(N1-N2)+(ni+1-n1)/NTr], wherein lambda is a laser wavelength, (i=1,2,---,n). According to the method, dynamic and real-time measurement of phases can be realized, a high resolution is achieved.
Owner:UNIV OF SHANGHAI FOR SCI & TECH

Method and apparatus for dark field interferometric confocal microscopy

A differential interferometric confocal microscope for measuring an object, the microscope including: a source-side pinhole array; a detector-side pinhole array; and an interferometer that images the array of pinholes of the source-side pinhole array onto a first array of spots located in front of an object plane located near where the object is positioned and onto a second array of spots behind the object plane, wherein the first and second arrays of spots are displaced relative to each other in a direction that is normal to the object plane, the interferometer also (1) imaging the first arrays of spots onto a first image plane that is behind the detector-side pinhole array, (2) imaging the first array of spots onto a plane defined by the detector-side pinhole array, (3) imaging the second array of spots onto a second image plane that is in front of the detector-side pinhole array, and (4) imaging the second array of spots onto the plane defined by the detector-side pinhole array, wherein each spot of the imaged first array of spots in the first image plane is aligned with a corresponding different spot of the imaged second array of spots in the second image plane and a corresponding different pinhole of the detector-side pinhole array, and wherein each spot of the imaged first array of spots in the plane defined by the detector-side array coincides with a corresponding different spot of the imaged second array of spots in the plane defined by the detector-side array and coincides with a corresponding different pinhole of the detector-side pinhole array.
Owner:ZETETIC INST

Sensor device and method for label-free detection of double strand nucleotides

A sensor device which is adapted for detecting target molecules having a target nucleic acid sequence located in nano/micro channels, comprises a THz source for exciting the target molecules and a heterodyne interferometer, having a detection frequency MHz, for probing the excited molecules. The nano-channel array in the sample holder is functionalized with electric field to linearize the target alleles and genes. The linearized molecules are exposed to THz field whereby the different vibrational modes of base pairs are resonantly excited. The excitation of base-breathing mode and base-shifting mode leads to differential induced dipole moments along and perpendicular to the double helix axis. This induced asymmetry in polarizability leads to optical anisotropy. The dipole-dipole interaction between adjacent bases affects polarizability along the helix axis and hence the intrinsic molecular anisotropy is a function of number of base pairs in the strand. The resulting birefringence can be measured using the heterodyne interferometer as a function of changes in the number of base pairs in the strand. Furthermore, a sensing method for detecting birefringence in terms of phase shift of the MHz signal, as a function of target molecule size, is described.
Owner:AIYER ARUN ANANTH

Design method of anisotropic super-hydrophobic surface of common nepenthes-imitating sliding area

ActiveCN111597728AAchieving controllable designAdjustable superhydrophobic effectDesign optimisation/simulationSpecial data processing applicationsSuperhydrophobeInterferome
The invention discloses an anisotropic super-hydrophobic surface design method of a common nepenthes-imitated sliding area. A scanning electron microscope and a three-dimensional white light morphology interferometer are used for carrying out micro-morphology observation on the common nepenthes sliding area and obtaining micro-morphology structure characteristic parameters; establishing an anisotropic super-hydrophobic surface bionic model imitating a common nepenthes slippage region according to the extracted micro-topography structure characteristic parameters; based on a Cassie-Baxter model, calculating a numerical relationship between anisotropic super-hydrophobic surface micro-topography structure characteristic parameters of a common nepenthes-imitating sliding region and a super-hydrophobic function; according to the derived numerical relationship, the super-hydrophobic effect of the anisotropic super-hydrophobic surface imitating the common nepenthes slippage region is regulated and controlled by regulating and controlling the characteristic parameters of the micro-morphology structure. According to the design method, controllable design of the super-hydrophobic effect canbe achieved, the super-hydrophobic effect of the designed super-hydrophobic surface can be regulated and controlled, and the design method further has the characteristics of anisotropy of the super-hydrophobic effect and the like.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY

System and method for measuring phase

Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light.These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imagingorigins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in theirnative state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and / or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference withinthe cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
Owner:MASSACHUSETTS INST OF TECH

A Method for Spatial Position Registration of Synchronous Phase-shifting Interferogram of Dynamic Interferometer

The invention discloses a space location registration method of a synchronous phase-shifted interferogram of a dynamic interferometer. The method comprises the following steps: firstly inclining a reference mirror in the dynamic interferometer, importing linear carrier frequency in the synchronous phase-shifted interferogram, collecting the carrier frequency synchronous phase-shifted interferogram, and dividing the carrier frequency synchronous phase-shifted interferogram into four sub-interferograms; solving phase information of each sub-interferogram by using Fourier filter method, and performing inclination elimination on the phase information to obtain to-be-measured phase information contained in each; and then selecting the phase information contained in one interferogram as standardphase information, determining a space location matching error of the phase information contained in other interferograms and the standard phase information by adopting a quick phase correlation registration method; and finally determining a location registration relation among the sub-interferograms according to the space location matching error of the phase information. The automation degree ofthe space location registration of the dynamic interferometer is improved, the accuracy and the reliability of the space location registration are improved, the method is simple and efficient and theapplicable range is wide.
Owner:NANJING UNIV OF SCI & TECH

Interferometer device and method for producing an interferometer device

The invention relates to an interferometer device (1), comprising: a substrate (2); an intermediate layer region (3), which is applied to the substrate (2); a first mirror device (SP1) and a second mirror device (SP2), which are oriented plane-parallel to one another, are spaced apart from one another by a first distance (d12) and are enclosed in or arranged on the intermediate layer region (3), the intermediate layer region (3) being removed below the first mirror device (SP1) and / or below the second mirror device (SP2) in an inner region (IB); and a laterally structured electrode (E), which comprises a first subregion (E1) and at least one second subregion (E2), which is laterally separated from and electrically insulated from the first subregion, which subregions can be connected to different electric potentials, wherein: the electrode (E) is spaced apart from the first or the second mirror device (SP1; SP2) by a second distance (d2); the first subregion (E1) runs in the inner region (IB) and is arranged on the intermediate layer region (3) and the second subregion (E2) runs in an outer region (AB) of the intermediate layer region (3), such that the first mirror device (SP1) and / or the second mirror device (SP2) can be moved electrostatically in the inner region (IB) by means of the first subregion (E1), parallel to the substrate (2), and the first distance (d12) can be varied.
Owner:ROBERT BOSCH GMBH
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