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19 results about "Interferome" patented technology

Interferome is an online bioinformatics database of interferon-regulated genes (IRGs). These Interferon Regulated Genes are also known as Interferon Stimulated Genes (ISGs). The database contains information on type I (IFN alpha, beta), type II (IFN gamma) and type III (IFN lambda) regulated genes and is regularly updated. It is used by the interferon and cytokine research community both as an analysis tool and an information resource. Interferons were identified as antiviral proteins more than 50 years ago. However, their involvement in immunomodulation, cell proliferation, inflammation and other homeostatic processes has been since identified. These cytokines are used as therapeutics in many diseases such as chronic viral infections, cancer and multiple sclerosis. These interferons regulate the transcription of approximately 2000 genes in an interferon subtype, dose, cell type and stimulus dependent manner. This database of interferon regulated genes is an attempt at integrating information from high-throughput experiments and molecular biology databases to gain a detailed understanding of interferon biology.

Interferometer error calibration method and device and computer readable storage medium

The invention discloses an interferometer error calibration method and device and a computer readable storage medium, and belongs to the technical field of measurement equipment.The method comprises the steps that measurement data collected when an interferometer moves on the x / y axis of a motion table is obtained, and x / y axis compensation amount is generated through calculation processing; meanwhile, a coordinate system transformation matrix is established and optimized by using data of a marking plate arranged on a motion table, and x-axis and y-axis non-orthogonal parameters are obtained. And then the compensation amount and the non-orthogonal parameters are input into a preset kinematic model, and the accurate position of the motion platform under the global coordinate system is calculated in real time. And when a preset updating condition is met, dynamically updating the error compensation value of the interferometer through the deviation between the actual position detected by the visual system and the calculated position. Reflector surface type error compensation and non-orthogonal parameter correction are fused, and high-precision error compensation calibration of the interferometer is achieved.
Owner:智慧星空(上海)工程技术有限公司 +1

Interferometric measurement method

PendingDE102024135315A1Using optical meansInterferomeOptical surface
In a method for the interferometric determination of the shape of a freeform optical surface of a test specimen using an interferometer, the specimen is successively positioned in different measurement positions. These positions include a nominal position and a multitude of non-nominal positions that deviate from it, each of which can be described by a change in position relative to the nominal position. An interferogram is recorded in each measurement position, and phase information derived from the interferogram is evaluated to determine the surface shape. An interferometer error tilt sensitivity is determined by means of position changes in the form of tilts. A shear of the surface form error is determined by means of position changes in the form of displacements. Through integration, the surface form error, and consequently the interferometer error, can be determined.
Owner:CARL ZEISS SMT GMBH

Double-path interferometer switching method and device and computer storage medium

ActiveCN120970478AUsing optical meansInterferomeComputer engineering
The invention provides a double-path interferometer switching method and device and a computer storage medium. The double-path interferometer switching method is applied to computer equipment in a workpiece measurement system. Firstly, the center position of the workpiece table is obtained according to a preset time interval, then switching adjustment parameters of the first interferometer and the second interferometer are determined based on the center position of the workpiece table, and the switching adjustment parameters comprise weights or offset values of the first interferometer and the second interferometer. The method comprises the following steps: acquiring a switching adjustment parameter of a first interferometer and a second interferometer, then acquiring measured values of the first interferometer and the second interferometer at the current moment, and finally, outputting an actual measured value based on the measured values of the first interferometer and the second interferometer and the switching adjustment parameter. Thus, according to the method, the switching adjustment parameters of the two-way interferometer can be adjusted according to the center position of the workpiece table, automatic switching of the two-way interferometer is achieved, and continuous actual measurement values of the interferometer are output.
Owner:TIANFU XINGLONG LAKE LAB

Interferometric test setup for testing the surface shape of a test object

PendingDE102024208940A1Using optical meansInterferomeReference wave
The invention relates to an interferometric testing arrangement for testing the surface shape of a test object, comprising a lighting device (105, 205, 305) for generating an input wave from electromagnetic radiation produced by a light source and an interferometer (150) in which, after splitting the input wave into at least one test wave directed towards the test object (170) and a reference wave, testing the surface shape of at least a partial surface of the test object (170) can be carried out by interferometric superposition of the at least one test wave and the reference wave, wherein a diffuser (130, 230, 330) is arranged in the lighting device, wherein the lighting device has a first optical path (110, 210, 310) and a separate second optical path (120, 220, 320), and wherein the input wave is transmitted via both the first optical path (110, 210, 310) and the second optical path (120, 220, 320). 220,320) can be coupled into the interferometer (150).
Owner:CARL ZEISS SMT GMBH

Flexible micro-nano fiber multiplexing chip and monitoring system and method thereof

This invention provides a flexible micro / nano fiber optic multiplexed chip and its monitoring system and method, belonging to the field of biomedical sensing technology. It includes: a myocardial marker detection layer with an embedded array of micro / nano fiber optic interferometers modified with different biological probes for simultaneous detection of multiple cardiovascular disease markers in sweat; a microfluidic channel layer with microfluidic channels for collecting and transmitting sweat and an outlet for sweat excretion; and a pulse wave monitoring layer with an embedded U-shaped micro / nano fiber for real-time pulse wave monitoring based on the bending loss principle, with a localized microfluidic channel inlet for sweat collection. Through the above technical solution, dual-modal multi-information synchronous monitoring is achieved, with high performance and high reliability.
Owner:HANDAN COLLEGE

Systems and methods for utilizing interferometric ultra-high resolution 3D imaging

The invention generally relates to systems and methods for utilizing interferometric ultra-high resolution 3D imaging. In certain aspects, the invention provides a system for achieving molecular resolution through tissues, the system comprising: an interferometric apparatus; and a control unit comprising one or more processors configured to: receive interferometric tissue data from the interferometric apparatus, wherein the interferonic tissue data comprises one or more tissue-induced abberations; apply a 4Pi in-situ point spread function (PSF) retrieval algorithm to the interferonic tissue data, thereby enabling direct retrieval of an aberrated, time-dependent in-situ model of single-molecule emission pattern from the interferonic tissue data, wherein the in-situ model reflects distortions, blurring, and / or partial coherence encountered during detection; and minimize disparities between the interferonic tissue data and the in-situ model to thereby provide accurate molecular localizations in the presence of tissue-induced aberrations.
Owner:PURDUE RES FOUND

Method for measuring transverse temperature of atomic group in atomic interferometer

ActiveCN120740793AThermometers using physical/chemical changesAtomic groupAtomic cluster
The invention belongs to the field of precision measurement, and particularly discloses a method for measuring the transverse temperature of an atomic group in an atomic interferometer. The method comprises the following steps: firstly, adjusting the starting time to control the size of an atomic group at the moment of acting on a Raman light pulse, and carrying out a Rabian oscillation experiment under different atomic group sizes; performing trigonometric function fitting on the experimental data, and extracting key parameters reflecting the transverse temperature from the experimental data; and finally, performing inversion calculation to obtain the transverse temperature of the atomic group. The method is based on Gaussian distribution of atomic group density and Raman light intensity in a transverse space, and a coupling result of the atomic group density and the Raman light intensity shows non-uniformity of atomic transition in the transverse space, so that the overall average transition probability of an atomic group, namely the linetype of a Rahis oscillation curve, is influenced; on the contrary, the line type of the Rabian oscillation of the atomic group contains the transverse parameter of the atomic group, and the transverse parameter of the atomic group is extracted from the line type of the Rabian oscillation. The method can be completed only by means of the atom interferometer, and is low in equipment requirement, simple in process and easy to operate.
Owner:HUAZHONG UNIV OF SCI & TECH

Interferometer direction finding result quality assessment method, device and medium

The application discloses an interferometer direction finding result quality evaluation method, equipment and medium, wherein the evaluation method comprises the following steps: performing reverse calculation on the theoretical phase difference by using the azimuth of direction finding and the baseline length; then, based on the difference between the real measurement phase difference and the theoretical phase difference of each baseline, calculating the threshold value by using the signal-to-noise ratio and the maximum phase difference tolerance during the design of the antenna baseline; then, obtaining the direction finding result quality evaluation of each baseline by using the relationship between the difference and the threshold value; finally, performing result fusion on the direction finding result quality evaluation data of each baseline by multiplication, so as to obtain the final interferometer direction finding result quality evaluation. The direction finding result quality evaluation data can be used to evaluate whether the interferometer direction finding result is reliable, so as to prevent the problem of performance decline of the equipment due to the direction finding error.
Owner:SOUTHWEST CHINA RES INST OF ELECTRONICS EQUIP

Three-dimentional shape measurement system and correlative measurement method using interferometer and atomic force microscope

The present disclosure relates to a three-dimensional shape measurement system and measurement method using an interferometer and an AFM. In particular, the present invention relates to, as a three-dimensional shape measurement device of a measurement object through an interferometer and an AFM, a three-dimensional shape measurement system using the interferometer and an AFM including: an interference unit that measures a shape of a measurement object (2); and an AFM unit (200) that measures the measurement object, has an active cantilever beam (150) moved through a 3-axis piezo actuator, and measures the boundary of a specific area of the measurement object (2).
Owner:NANO ANALYTIC GMBH +1

An interferometer direction finding resolution unscrambling method, system and medium for a shaped array

The application discloses an interferometer direction-finding demodulation method, system and medium for a special-shaped array, and the method comprises the following steps: selecting two pairs of baseline longest antenna elements to form a first interferometer; calculating the maximum ambiguity number of the interferometer measurement phase difference according to the interferometer vector of the first interferometer, and calculating the target unit vector coordinate estimation value corresponding to all ambiguity combination in the range with the maximum ambiguity number as the boundary; forming a corresponding second interferometer with the remaining antenna elements, calculating the cost function corresponding to all ambiguity combinations according to the target unit vector coordinate estimation value and the measurement phase difference of each pair of second interferometers; searching for the minimum value of the cost function, taking the ambiguity combination corresponding to the minimum value of the cost function as the ambiguity number estimation result, obtaining the target unit vector coordinate estimation value corresponding to the ambiguity number estimation result, and calculating the corresponding azimuth and elevation angle estimation value. The application solves the problem of interferometer direction-finding demodulation of a special-shaped array.
Owner:HUNAN ECONOVEL TECH CO LTD

Interferometric test arrangement for testing the surface shape of a test object

PCT designated stageWO2026061702A1Using optical meansLight spotInterferome
The invention relates to an interferometric test arrangement for testing the surface shape of a test object, comprising an illumination device (105, 205, 305) for generating an input wave from electromagnetic radiation generated by a light source, and an interferometer (150) in which, after the input wave has been split into at least one test wave directed onto the test object (170) and a reference wave, the surface shape of at least one partial surface of the test object (170) can be tested by interferometrically superimposing the at least one test wave and the reference wave, wherein a diffusing plate (130, 230, 330) is arranged in the illumination device, wherein the illumination device has a first optical path (110, 210, 310) and, separate therefrom, a second optical path (120, 220, 320), wherein the input wave can be coupled into the interferometer via both the first optical path and the second optical path, wherein, when the input wave is coupled in via the first optical path, a light spot generated on the diffusing plate has a first diameter (D1), and wherein, when the input wave is coupled in via the second optical path, a light spot generated on the diffusing plate has a second diameter (D2) which differs from the first diameter (D1). (Figure 1a)
Owner:CARL ZEISS SMT GMBH

Rotating Interferometric Imaging Spectroscopic Microscopy System and Apparatus

This invention provides a rotating interferometric imaging spectroscopic microscopy system and apparatus. Light emitted from a multi-band LED light source passes through a multi-band fluorescence filter to obtain narrowband light, which then enters an oil immersion lens to illuminate a fluorescently labeled sample. The excitation light from the fluorescently labeled sample passes through the multi-band fluorescence filter into a rotating Sagnac interferometer, forming two transversely sheared interference beams. These beams are then converged through a Fourier lens onto the image plane of a high-sensitivity camera, generating an interference image. The high-sensitivity camera continuously acquires multiple frames of interference images. A computer processing module performs multi-frame interference image registration and Fourier transform to achieve spectral reconstruction, obtaining a unified spectral data cube that includes both two-dimensional image information and one-dimensional spectral information of the fluorescently labeled sample. This invention utilizes interferometry to obtain the spectral information of all pixels in the sample, offering high light throughput and high reliability, thus improving the imaging system's resolution of fluorescently labeled samples.
Owner:SHANGHAI JIAOTONG UNIV

Method for fabricating a reference element for an interferometer

The present application relates to a method (10) of fabricating a reference element (14) of an interferometer configured to measure the surface shape of a test object, the reference element (14) including a first surface (16) that is transparent to measurement radiation of the interferometer and serves as a reference surface for the interferometric measurement of the test object. The method (10) includes the steps of generating (60) a first interferogram by superimposing a first measurement wave (64) generated by reflection at a reference surface (16) with a second measurement wave (66) generated by interaction with a standardized test object (32), generating (70) a second interferogram by superimposing (70) the first measurement wave (64) generated by reflection at the reference surface (16) with a third measurement wave (72, 172) passing through a beam path (73, 173) different from the beam path (67) passed by the second measurement wave, evaluating (68, 74) the first interferogram and the second interferogram, and processing (78) a first surface (16) and another surface (62) opposite the first surface (16) of the reference element (14) based on the evaluation. The invention further relates to a corresponding device (12) for processing the reference element (14).
Owner:CARL ZEISS SMT GMBH

Hydrogel functionalized optical fiber cortisol sensor and preparation method thereof

PendingCN121431439APhase-affecting property measurementsAntigenConcentration Response
The invention provides a hydrogel functionalized optical fiber cortisol sensor and a preparation method thereof, and belongs to the technical field of optical fiber biomass sensing. The effective refractive index of the hydrogel film coated on the surface of the optical fiber in the sensing area is changed by utilizing antigen-antibody specific binding, so that the effective refractive index of the sensing arm of the optical fiber Mach-Zehnder interferometer in the sensing area is changed, and the interference spectrum of the sensor is changed; by demodulating cortisol concentration response of a sensor interference spectrum, concentration measurement of cortisol to be measured can be realized, and high-sensitivity and specific recognition of cortisol is realized; in addition, the hydrogel functionalized optical fiber cortisol sensor provided by the invention is stable in structure, high in integration level and high in sensitivity, and can be used for accurately measuring the concentration of cortisol in media such as saliva.
Owner:HARBIN UNIV OF SCI & TECH

A click chemistry coupled biosensing method for antibiotic resistance gene detection

The application provides an antibiotic resistance gene detection method of click chemistry coupling biosensing, which can realize the recognition and detection of the femtomole level of the resistance gene (ARG) in water. First, the capture DNA is fixed on the streptavidin biosensor surface of a multi-channel bio-interferometer. In the presence of the target ARG, the capture DNA and the signal DNA are hybridized to the adjacent positions of the target ARG, so as to form a “click” structure. Then, the horseradish peroxidase is used to label the biosensor with the “click” structure, and the biosensor is immersed in the diaminobenzidine substrate, so that the insoluble crystal is deposited on the biosensor surface, the thickness of the biosensor tip biological layer is changed, the wavelength shift caused thereby and the linear relationship of the target ARG concentration are obtained, and the resistance gene in the sample to be detected is quantitatively detected. The method realizes the super-sensitivity and high selectivity detection of the resistance gene in the water environment.
Owner:EAST CHINA NORMAL UNIV

OFDR type esophageal squamous carcinoma marker detection device and functionalization and detection method

The invention discloses an OFDR type esophageal squamous carcinoma marker detection device and a functionalization and inspection method, and relates to the field of distributed optical fiber biochemical sensing, the device comprises a light splitting assembly, an interference assembly and a demodulation processing assembly, the light splitting assembly is used for splitting frequency linear tuning laser into auxiliary interferometer light and main interferometer light, and the interference assembly is used for receiving the auxiliary interferometer light and the main interferometer light; and splitting the primary interferometer light into reference light and measurement light; the demodulation processing assembly is used for collecting interference signals and calculating wavelength drift results of the stepped conical optical fiber in various refractive index environments in combination with a cross-correlation algorithm and a reference RBS signal; the main interferometer comprises a stepped conical optical fiber used for receiving measuring light and generating backward Rayleigh scattering light, and the stepped conical optical fiber comprises a first target conical region of a middle thin conical region part and second target conical regions located on the two sides of the first target conical region. According to the application, the high-precision detection of the Cyfra21-1 protein concentration in the serum of the esophageal squamous carcinoma patient can be realized.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

OFDR type esophageal squamous cell carcinoma marker detection device and functionalization and inspection method

The application discloses an OFDR type esophageal squamous cell carcinoma marker detection device and a functionalization and inspection method, relates to the field of distributed optical fiber biochemical sensing, and comprises a light splitting assembly, an interference assembly and a demodulation processing assembly. The light splitting assembly is used for splitting a frequency linearly modulated laser into auxiliary interferometer light and main interferometer light, and splitting the main interferometer light into reference light and measurement light. The demodulation processing assembly is used for collecting interference signals, and combining a cross-correlation algorithm and a reference RBS signal to calculate wavelength drift results of the stepped taper optical fiber in various refractive index environments. The main interferometer comprises a stepped taper optical fiber used for receiving measurement light and generating back Rayleigh scattering light. The stepped taper optical fiber comprises a first target taper region of a middle thin taper region part and a second target taper region located on both sides of the first target taper region. The application can realize high-precision detection of the Cyfra21-1 protein concentration in the serum of an esophageal squamous cell carcinoma patient.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV