The invention relates to an intraoperative probe for guiding an excision tool, comprising a detection head, said detection head comprising a plurality of optical fibers each coupled to a
photodetector characterized in that said optical fibers are transparent and
scintillator-free, the proximal end of each of said transparent fibers is optically coupled with a single continuous
scintillator optically coupled to a
light guide, capable of capturing beta and / or gamma particles and emitting light in response to this interaction, the distal end of each of said transparent fibers is coupled to a
photodetector, and in that said intraoperative probe is associated with a
signal processing system, configured to analyze the signals delivered by said photodetectors.comprising: a means for temporal
coincidence analysis of said signals delivered by said photodetectors to discriminate real events from thermal
noise; a
processing means enabling the reconstruction of the interaction position of particles in said continuous
scintillator from the distribution of light transmitted by said optical fibers. Figure of the abstract: 1,