The invention provides an intelligent life prolonging control method for reuse of a retired aero-engine, which comprises the following steps: establishing a thermal mechanical fatigue life model according to engine performance parameters and turbine guide vane material characteristic parameters; designing different acceleration limiting plans in the early acceleration stage, the middle acceleration stage and the later acceleration stage respectively; in order to prolong the service life and improve the dynamic performance, constructing an objective function by adopting an evaluation function method, and converting a multi-objective optimization problem into a single-objective optimization problem; and adding the thermal mechanical fatigue life model and the acceleration limit plan into a main controller, performing joint simulation with the engine complete machine model, obtaining each parameter value in the acceleration limit plan through continuous optimization iteration, and determining the final acceleration limit plan as a life extension control rule. According to the method, only the acceleration control rule of the retired aero-engine needs to be modified and optimized, hardware of an engine body and a controller does not need to be changed, the modification difficulty is small, the cost is low, and the effect is obvious.