The invention discloses a large-sized bridge type gantry mixed machining machine tool which is characterized by comprising a base (1), a working corridor (2), a machine tool body (3), an X-axis feeding system (4), a cross beam (5), a Y-axis feeding system (8), a slide carriage (7), a square ram (11), a Z-axis feeding system (12), a C-axis feeding system, an A-axis feeding system, an actuation mechanism interface (13) and an actuation unit library (15). By combination of a modern additive manufacturing process and a milling process, efficient and precision machining of a large-size die is realized, and the efficiency is 10 times or much higher than that of machining with a conventional die, but the cost is only 30 percent of that of a conventional process; and the large-sized bridge type gantry mixed machining machine tool meets a customization requirement and intelligence and flexibility requirements in the future and has good prospect. The large-sized bridge type gantry mixed machining machine tool replaces a conventional casting die, can quickly make a response to a demand of a client, and saves the die investment by 60 percent or above.