The invention discloses an anti-seismic fire-resistant steel plate with the thickness being 100mm and the yield strength being the 460MPa grade and a manufacturing method thereof. The anti-seismic fire-resistant steel plate is characterized by comprising, by weight, 0.06-0.12% of C, 0.10-0.50% of Si, 0.90-1.60% of Mn, smaller than 0.015% of P, smaller than 0.01% of S, 0.20%-0.70% of Cr, 0.15-0.22%of Mo, 0.065-0.110% of Nb, 0.015%-0.045% of V, 0.01%-0.04% of Ti, 0.01%-0.04% of Al, smaller than 0.0060% of N and the balance Fe and inevitable impurity elements. The low-molybdenum and high-niobiumcomponent design thought is adopted, the cost of steel is effectively reduced through the low-molybdenum design, and the high-temperature performance is improved through precipitation strengthening of niobium at the high temperature; meanwhile, a certain number of bainite structures are generated by the steel through the means of controlled rolling and controlled cooling, and the high-temperaturestrength of the steel is regulated and controlled through the good high-temperature performance of bainite; and the rolling mode is hot rolling, the production cost is reduced, and great applicationprospects and economic benefits are achieved.