The invention discloses a preparation process of a heat-clearing and detoxifying veterinary traditional Chinese medicine. The veterinary traditional Chinese medicine is prepared from the following components in parts by weight: 3-6 parts of folium isatidis, 5-7 parts of radix isatidis, 5-7 parts of gypsum, 5-6 parts of rheum officinale, 4-5 parts of compound of glauber-salt and liquorice, 4-6 parts of pericarpium citri reticulatae, 4-6 parts of astragalus membranaceus, 5-7 parts of scutellaria baicalensis, 3-5 parts of cinnamon, 3-6 parts of fried yam, 1-3 parts of codonopsis pilosula, 3-5 parts of Lysimachia christinae hance, and 3-5 parts of schizonepeta. By using a freeze dryer provided by the invention, the problems that an existing vacuum heating drying method enables active pharmaceutical substances with poorer heat resistance to lose activity, and volatile active pharmaceutical substances are easy to volatilize and lose in the heating drying process can be solved.