The invention discloses a gypsum-based waterproof, fireproof, containment and heat-insulation system for a steel-structure house and a preparation method for the same. The system and the method relate to the technical field of steel-structure house containment structures. The gypsum-based waterproof, fireproof, containment and heat-insulation system for the steel-structure house disclosed by the invention comprises a base material layer, an outer interface layer, an outer heat-insulation layer, an outer protection layer, an inner interface layer, an inner fireproof layer, an inner heat-insulation layer, an inner protection layer and an inner facing layer, wherein the outer interface layer is disposed on the outer side of the base material layer, the outer heat-insulation layer is disposed on the outer side of the outer interface layer, and the outer protection layer is disposed on the outer side of the outer heat-insulation layer; and the inner interface layer is disposed on the inner side of the base material layer, the inner fireproof layer is disposed on the inner side of the inner interface layer, the inner heat-insulation layer is disposed on the inner side of the inner fireproof layer, the inner protection layer is disposed on the inner side of the inner heat-insulation layer, and the inner facing layer is disposed on the inner side of the inner protection layer. According to the invention, a machine spray coating operation is applied, forming technologies are simple, operations are convenient, and production efficiency is high; a lot of gypsum is used as a material, so that a cement demand is reduced and cracking does not take place easily; the gypsum fireproof material contains crystal water which can absorb heat in a fire and form water vapor, so that fireproof effects are good; and a compact grid structure is formed by gypsum-based waterproof and heat-insulation mortar and has good waterproof performance.