The invention relates to a self-adsorption inertial stick-slip cross-scale precision motion platform based on interface effect, and belongs to the field of cross-scale precision motion. The self-adsorption inertial stick-slip cross-scale precision motion platform based on the interface effect is provided with an inertial block, a moving block, a piezoelectric ceramic and a moving surface arrangedat the bottom of the moving block, wherein the moving block is arranged below the inertial block, a micro-nano structure is arranged on the moving surface, the lower end of the moving surface is in contact with a metal surface and generates frictional force, the inertial block is provided with a mounting surface, an accommodating groove penetrating through the inertial block is arranged on the mounting surface along the center position of the inertial block, the piezoelectric ceramic is placed in the accommodating groove, and a fixed wall and an elastic wall are respectively arranged on the left and right sides of the accommodating groove. The scheme of the invention has the advantages of simple structure, small volume, simple manufacturing process and low manufacturing cost, and can realize cross-scale precision positioning; and in addition, since a magnet is arranged in a cavity, the frictional force of the inertial block and the moving block can be improved, so that the motion of the platform can be more stable.