The invention discloses an on-site grouting system and a method for reinforcing flocculated sludge by combining vacuum preloading and grouting. The on-site grouting system is composed of an engineering mechanical vehicle, a grouting pipe, a vertical drainage plate, a control electric box, a foam plate, a flocculant pump, a vacuum pump and some conveying pipelines. According to the method for reinforcing the flocculated sludge by combining vacuum preloading and grouting, lime pipe grouting is used as a main process, traditional vacuum preloading is improved through an electrical control technology, modern mechanical equipment is adopted for construction, and therefore, the high efficiency and refinement of construction are achieved, the construction process is simplified, manpower participation is reduced, the safety coefficient of labor is increased, and the working efficiency is greatly improved; and the requirement of traditional vacuum preloading on a site is reduced through a lime grouting mode, the flocculation effect in a soil body is improved, the application range of vacuum preloading is widened, the flocculation effect in the soil body is improved, and the construction period is greatly shortened.