The invention relates to the technical field of cables, in particular to an anti-nuclear radiation semi-flexible coaxial signal transmission cable which can operate within the temperature range of minus100 DEG C to +150 DEG C for a long time, and has the radiation intensity more than 1*106Gy. The cable comprises an inner conductor, an insulating layer, an outer conductor and a jacket layer, is mainly used for transmitting and detecting an equipment operation signal in the nuclear island of a nuclear power station, and is also used for nuclear submarines. The anti-nuclear radiation semi-flexible / semi-rigid coaxial cable of the invention is prepared by extruding an injection molding material, namely polysulfone (PSU) plastic on the common fluorine plastic extrusion production line through a YJTB technique comprising the following steps: PSU material preprocessing, extrusion auxiliary device designing, extrusion process parameter matching and optimization design, process temperature gradient screening and controlling, cooling speed controlling and the like.