The invention discloses a high-performance high-reliability reference voltage source of a low-voltage complementary metal oxide semiconductor (CMOS). The high-performance high-reliability reference voltage source comprises a starting circuit, an automatic biasing voltage generating circuit, a main bias current generating circuit and a reference voltage generating circuit, wherein direct current input ends of the starting circuit, the automatic biasing voltage generating circuit, the main bias current generating circuit and the reference voltage generating circuit are connected with a direct current power source VDD, the starting circuit and the automatic biasing voltage generating circuit are connected with the main bias current generating circuit, the automatic biasing voltage generating circuit generates stable bias voltage by means of feedback with the main bias current generating circuit and transmits the stable bias voltage to the main bias current generating circuit, the main bias current generating circuit is connected with the reference voltage generating circuit, and reference voltage Vref with low power consumption and low temperature coefficient is output by the reference voltage generating circuit. According to the high-performance high-reliability reference voltage source of the low-voltage CMOS, the CMOS reference voltage source is easy to implement in the CMOS process, the compatibility is good, and high performance and high reliability can be achieved under low voltage.