The invention discloses a method for establishing and analyzing a scale metabolism network model of actinoplanetes genomes, and belongs to the field of systems biology. Cell growth simulation, essential growth essential genes and reaction verification are carried on the scale metabolism network model of actinoplanetes genomes established based on the method on a system level, a strategy is provided for simulating and improving acarbose yield, and an important platform is provided for comprehensively understanding the metabolic characteristics of actinoplanetes and improving the acarbose fermentation level. The invention provides multiple methods for improving the acarbose yield, the acarbose yield can be increased by 53.5% by adding nicotinic acid, and the acarbose yield is respectively increased by 29.6%, 26.5%, 26.3%, 11.8% and 9.2% by adding glutamic acid, cysteine, lysine, glutamine and asparagines.