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32 results about "Phosphole" patented technology
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Phosphole is the organic compound with the chemical formula C₄H₄PH; it is the phosphorus analog of pyrrole. The term phosphole also refers to substituted derivatives of the parent heterocycle. These compounds are of theoretical interest but also serve as ligands for transition metals and as precursors to more complex organophosphorus compounds.
Modular cytomimetic biomaterials, transport studies, preparation and utilization thereof
The present invention provides a biocompatible material, comprising a phospholipid or phospholipid derivative comprising various functional groups having specific chemical properties, which can function as a modular surface design unit to be incorporated or appended to a desired substrate on which it is then polymerized, thereby contributing new or specified biochemical characteristics to the polymerized and stabilized biomaterial.
Owner:EMORY UNIVERSITY
Method for preparing filling leather fatliquoring agent
The invention provides a method for preparing a filling leather fatliquoring agent, comprising the following steps: (1) a component A and a component B or a component A, a component B and a component C undergo copolymerization in the presence of initiators, wherein the component A is at least one of natural oil containing unsaturated fatty acid, long carbon chain unsaturated fatty acid, ester of long carbon chain unsaturated fatty acid and long carbon chain unsaturated fatty acid amide; the component B is at least one of acrylic acid, methacrylic acid, ethyl acrylic acid, maleic acid, fumaric acid, glutaconic acid, vinyl acetic acid, maleic anhydride and glutaconic acid anhydride; and the component C is at least one of styrene, vinylacetate, vinyl propionate, acrylate, methacrylate, acrylamide and methacrylamide; (2) alkali is added in polymers generated after copolymerization to undergo neutralization reaction with the polymers; and (3) the neutralized polymers are mixed with the natural phospholipids. The method is economical and environmentally friendly.
Owner:ZHEJIANG IND & TRADE VACATIONAL COLLEGE
Method for catalytically hydrolyzing phosphatide bond of organic compound by virtue of cerium-based metal-organic frameworks
InactiveCN106824277AIncrease productionIncrease manufacturing costOrganic-compounds/hydrides/coordination-complexes catalystsPhosphateChemical compound
The invention relates to catalytic hydrolysis of a phosphatide-bond-containing organic compound, and particularly discloses a method for catalytically hydrolyzing a phosphatide bond of an organic compound by virtue of cerium-based metal-organic frameworks. The method specifically comprises the following steps: (1) ultrasonically and uniformly dispersing the cerium-based metal-organic frameworks in ammonia water; (2) adding the phosphatide-bond-containing organic compound into a solution of the cerium-based metal-organic frameworks obtained in step (1), performing oscillation for complete reaction, and extracting a fixed amount of reaction solution for centrifugal testing. According to the method, the phosphatide-bond-containing organic compound such as p-nitropenyl phosphate disodium (pNPP), dimethyl p-nitrophenyl phosphate and diethyl p-nitrophenyl phosphate is catalytically hydrolyzed by virtue of the cerium-based metal-organic frameworks, a semiautomatic perfusion system is constructed, and a high application value is achieved.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Lipoid bio-degradable polyester and preparation thereof
A phosphatidic biological degradable polyester and its production are disclosed. The production is carried out by phosphatidic group of phosphoryl choline with bionic function condensing reacting, covalent interlinking onto biological degradable polymer chain, and obtaining degradable polymer with phosphatide modification. It achieves good biological degradability, biological compatibility, and self-combing ability for medicine releasing carrier materials.
Owner:FUDAN UNIV
Method for preparing dibenzophosphole derivants
ActiveCN103214521AVarious types of productsLow costGroup 5/15 element organic compoundsOrganic synthesisOrganic solvent
The invention discloses a method for preparing dibenzophosphole derivants. The method comprises the following steps of: taking manganese acetate as an accelerant and a diphenylphosphine oxide derivant as a reactant, and reacting in an organic solvent to obtain the dibenzophosphole derivant, wherein a structural formula of the diphenylphosphine oxide derivant is as shown in specification. According to the method, the diphenylphosphine oxide derivant which is well-sourced is used as an inhibitor to react, and therefore, various types of products can be obtained; the diphenylphosphine oxide derivant can be directly used or used for other organic synthesis reactions without anhydrous and anaerobic conditions, wherein the reaction temperature is 20-120 DEG C, the reaction conditions are mild, the reaction operation and posttreatment processes are simple, the cost is low and the yield of the target product is high.
Owner:翁后科
Enhancement of magnesium uptake in mammals
InactiveUS8017160B2Enhancing magnesium uptakeBiocideMetabolism disorderMagnesium saltCarboxylic acid
Disclosed are methods and complexes for increasing magnesium uptake in mammals. Increasing magnesium uptake in mammals is accomplished by concurrently administering one or more magnesium salts with one or more quaternary amines and / or phosphatides and one or more di- or tri-carboxylic acids.
Owner:RMJ160 LLC
Synthesis method of benzo[b]phospholes
InactiveCN106831876AImprove toleranceGroup 5/15 element organic compoundsSolid-state devicesChemical synthesisDichlorophenylphosphine
The invention belongs to the organic chemical synthesis field and in particular relates to a synthesis method of benzo[b]phospholes. The synthesis method comprises the following steps: taking 1-substitued-2-bromoaryl-acetylene as a raw material, adding a dichlorophenylphosphine synthesis intermediate, and then generating a target compound through trace air catalysis. The synthesis method provided by the invention has the advantages that an oxidant, a catalyst and an additive do not need to be additionally added, and tolerance on different functional groups is good, so that the synthesis method is an environment-friendly synthesis method for a benzo[b]phospholes compound; the yield reaches more than 40%, so that the synthesis method has a good application prospect.
![Synthesis method of benzo[b]phospholes](https://images-eureka.patsnap.com/patent_img/0f23fbf0-9845-42c8-a794-1f8c60ebf4fc/170228154908.png "Synthesis method of benzo[b]phospholes")
![Synthesis method of benzo[b]phospholes](https://images-eureka.patsnap.com/patent_img/0f23fbf0-9845-42c8-a794-1f8c60ebf4fc/170228155305.png "Synthesis method of benzo[b]phospholes")
![Synthesis method of benzo[b]phospholes](https://images-eureka.patsnap.com/patent_img/0f23fbf0-9845-42c8-a794-1f8c60ebf4fc/BDA0001234834210000011.png "Synthesis method of benzo[b]phospholes")
Owner:ZHENGZHOU UNIV
Oridonin-loaded micelle preparation and preparation method thereof
InactiveCN101708154AGood water solubilityImprove stabilityOrganic active ingredientsPowder deliverySolubilitySide effect
The invention discloses an oridonin-loaded micelle preparation which comprises the raw materials of oridonin, cholate and phosphatide. An associated structure of the cholate and the phosphatide is used as a carrier of the oridonin, the water solubility of the oridonin is greatly improved through reasonably setting the proportion of the components, and the stability of the preparation is good. The micelle preparation has high drug-loading rate and easy control; the raw materials have not side and toxic effects, safety and reliability, wide source and low cost, and thus the micelle preparation is very suitable for wide clinical application. The preparation method has simple process, easy implementation, good repeatability, and suitability of large-scale production; and the liquid micelle preparation can be frozen to form frozen powder, thereby being more convenient for storage and transportation.
Owner:ARMY MEDICAL UNIV
Phosphole and diphosphole ligands for catalysis
InactiveUS6903182B2Group 8/9/10/18 element organic compoundsGroup 5/15 element organic compoundsPhosphoric acidAlkene
Novel reactions used to prepare phosphole and bisphosphole compounds are detailed. Novel phosphole compounds and metal coordination compounds of phosphole and bisphosphole compounds are also provided. These metal coordination compounds are useful as catalysts for the polymerization or olefins with carbon monoxide and for the polymerization of acrylic monomers.
Owner:EI DU PONT DE NEMOURS & CO
Biological analogue material with surface nano array and its preparing method
InactiveCN1512181AGroundbreakingImprove stabilityPharmaceutical containersMedical packagingChemical synthesisBiocompatibility Testing
The present invention relates to biological analogue material and is especially one kind of biological analogue material with surface nano matrix and its preparation process. The material includes substrate, one single self-assembled layer connected to the substrate and one phosphatide layer connected to the self-assembled layer. The phosphatide layer makes the present invention possess biocompatibility. The present invention combines the electronic beam printing technology and the solid support lipoid film for the first time to obtain solid supported lipoid film with surface nano array. Via chemical synthesis, phosphatide is made to joint with nano array. Meanwhile, biological material printing technology in molecular level is provided creatively.
Owner:INST OF CHEM CHINESE ACAD OF SCI
Application of Phosphatidylinositol4-kinase type II alpha PI4KIIalpha
ActiveCN101560546AStrong specificityLittle side effectsOrganic active ingredientsSenses disorderDiseaseFactor ii
The invention discloses a new biological function of Phosphatidylinositol4-kinase type II alpha PI4KIIalpha and an application based on the new function. PI4KIIalpha plays a key role in regulating andcontrolling a hypoxia-inducible factor HIF-1alpha and a downstream vascular endothecial growth factor VEGF. The selective reduction of PI4KIIalpha expression can obviously inhibit tumor growth and tumor angiogenesis. The PI4KIIalpha can be used as a target molecule for intervening in diseases which are relevant to a gene regulated and controlled by the HIF-1alpha and the diseases which are relevant to angiogenesis. In addition, the target molecule can be used for screening medicines for the relevant diseases.
Owner:INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
Phospholipid compound and preparation method thereof
InactiveCN110256485ARapid Fracture DegradationGroup 5/15 element organic compoundsPhosphatide foodstuff compositionsCarbonyldiimidazoleDisulfide bond
The invention discloses a phospholipid compound and a preparation method thereof. The structural general formula of the phospholipid compound is shown in the specification. In the formula, m is a positive integer from 2 to 10, and n is a positive integer from 7 to 15. The compound contains a disulfide bond easy to break and can be quickly broken and degraded in a reducing medium. The method comprises the following steps: (1) dissolving triphenylmethyl protected mercapto n-alkanoic acid into dimethyl sulfoxide, adding N,N'-carbonyl diimidazole, 1,8-diazabicyclo[5.4.0]undecane-7-ene and choline glycerophosphate, and carrying out a reaction to obtain bis-triphenylmethyl mercapto n-alkanoic acid choline glycerophosphate; 2) dissolving the bis-triphenylmethyl mercapto n-alkanoic acid choline glycerophosphate in dichloromethane, adding trifluoroacetic acid and triethylsilane, and carrying out a reaction to obtain bis-mercapto-alkanoic acid choline glycerophosphate; and 3) dissolving the bis-mercapto-alkanoic acid choline glycerophosphate in dichloromethane, adding n-alkyl dithiopyridine, and carrying out a reaction to obtain the bis-n-alkyl dithio-n-alkanoic acid choline glycerophosphate.
Owner:SOUTHEAST UNIV
Phospholipid compound containing unsaturated fatty acid derivative having cyclopropane ring
ActiveUS20150376213A1Easy transferOrganic active ingredientsNervous disorderOctanoic AcidsPhosphatidylethanolamine
The invention provides a phospholipid compound containing unsaturated fatty acid having a cyclopropane ring such as 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) and 8-(2-octylcyclopropyl)octanoic acid (DCP-OA) and the like, particularly 1,2-o-bis-[8-{2-(2-pentyl-cyclopropylmethyl)-cyclopropyl}-octanoyl]-sn-glycero-3-phosphatidylethanolamine (diDCP-LA-PE), which has a cognitive function improving effect and an anti-diabetes action, and which is useful as a medicine such as a therapeutic drug for dementia, a therapeutic drug for diabetes and the like.
Owner:NISHIZAKI BIOINFORMATION RES INST
Cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester compound and preparation method thereof
InactiveCN104004020ANovel structureImprove stabilityGroup 5/15 element organic compoundsEpoxyPolyester
The invention relates to a cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester compound and a preparation method of the cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester compound. The structure of the compound is shown through the following formula in the specification. The preparation method includes the steps that at the temperature of 50 DEG C, trimethylchlorosilane is dripped to a solution of 1-epoxide phosphole -4-hydroxymethyl-2, 6, 7-trioxa-bicyclo [2.2.2] octane (PEPA) and an organic solvent, the temperature rises to 80 DEG C to 140 DEG C, a reaction is conducted for 5 h to 11 h through stirring, a quantitative acid-binding agent is added, stirring is conducted for 1 h, when the pH of the solution is detected as 5 to 6, the reaction is ended, after reduced pressure distillation, purification treatment is conducted, and then cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester is acquired. The compound is an excellent halogen-free phosphorus and silicon synergistic flame-retardant charring agent, can be applied to polyolefin, polyester, polyvinyl chloride, polyurethane, epoxy resin, unsaturated polyester resin and the like, and is simple in process and small in equipment investment, and industrial production can be easily achieved.
Owner:SHANDONG XINGQIANG CHEM IND TECH RES INST CO LTD
Wound exudate responsive controlled released hydrogen sulfide probe and preparation method and application thereof
ActiveCN113402487AReal-time self-monitoringEfficient releaseOrganic active ingredientsOrganic chemistryFuranPhenyl group
The invention belongs to the technical field of medical materials, and discloses a wound exudate responsive controlled released hydrogen sulfide probe and a preparation method and application thereof. The wound exudate responsive controlled released hydrogen sulfide probe is more than one of a formula I or a formula II; R in the formula I and R in the formula II are respectively phenylene, thienyl, furylidene, pyrrolidene and phosphoropentadiene without two hydrogen atoms; R1 and R2 are independent hydrogen, C1-6 alkyl groups, C1-6 alkyloxy groups and C1-6 alkyl sulfenyl groups. The method comprises the following steps: 1) dissolving a precursor compound in an organic solvent to obtain a precursor compound solution; preparing a compound containing S < 2-> or HS <-> into a solution to obtain a sulfur-containing solution; and 2) mixing the precursor compound solution with a sulfur-containing solution to obtain the probe. The probe provided by the invention can realize quick and efficient release of hydrogen sulfide in response to wound exudate or water and real-time self-monitoring; the wound repair can be promoted, and the repair effect is good.
Owner:SOUTH CHINA UNIV OF TECH
Stable and strong anti-interference phospholipid detection reagent and detection method thereof
InactiveCN106404683AImprove stabilityLow priceColor/spectral properties measurementsPeroxidaseBis-tris propane
The present invention relates to the technical field of phospholipid detection, particularly to a phospholipid detection reagent. According to the present invention, a sodium citrate buffer solution and a Bis-Tris Propane (1,3-bis[tris(hydroxymethyl)methylamino]propane) buffer solution are respectively used in reagents R1 and R2, wherein the Bis-Tris Propane buffer solution used in the reagent is a biological buffer solution, provides good protection effects for the peroxidase used in the reagent, and does not adversely affect the reaction system, the reagent R1 contains phospholipase D, DAOS, a Triton X-305 solution, Emulgen 707, a reducing protection agent, a chelating protection agent and a preservative, and the reagent R2 contains a buffer solution, 4-aminoantipyrine, peroxidase, choline oxidase, and a preservative; and the phospholipid detection reagent has advantages of good stability and low cost, and can be widely used in the field of phospholipid detection.
Owner:BIOBASE BIODUSTRY (SHANDONG) CO LTD
Synthesis method of halauxifen-methyl
PendingCN122059873AOrganic chemistryOrganic-compounds/hydrides/coordination-complexes catalystsPtru catalystFormate
The invention discloses a synthesis method of halauxifen-methyl. The halauxifen-methyl is obtained by carrying out Suzuki coupling reaction on 4-amino-6-bromo-3-chloro-5-fluoropyridine carboxylic acid benzyl ester and 4-chloro-2-fluoro-3-methoxyphenylboronic acid, a catalytic system adopted by the Suzuki coupling reaction is a palladium catalyst, a phosphine ligand and a phase transfer catalyst; wherein the phosphine ligand is 4-(anthracene-9-yl)-3-(tert-butyl)-2, 3-dihydrobenzo [d] [1, 3] oxaphosphorus pentadiene, and the phosphine ligand is 4-(anthracene-9-yl)-3-(tert-butyl)-2, 3-dihydrobenzo [d] [1, 3] The molar use amount of the palladium catalyst is 0.1 to 0.5 mol percent of the molar use amount of the 4-amino-6-bromo-3-chloro-5-fluoropyridine benzyl formate. According to the invention, AntPhos is used as a phosphine ligand to form a catalytic system together with the palladium catalyst and the phase transfer catalyst, so that higher reaction yield and product purity can be obtained with very low dosage of the palladium catalyst, the synthesis cost of the halauxifen-methyl can be greatly reduced, the reaction condition is mild, the energy consumption is lower, and the method is suitable for industrial production.
Owner:江苏省农用激素工程技术研究中心有限公司
Caged flame-retardant char-forming agent trimethylsilicate pepa compound and preparation method thereof
InactiveCN104004020BNovel structureImprove stabilityGroup 5/15 element organic compoundsEpoxyPolyester
The invention relates to a cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester compound and a preparation method of the cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester compound. The structure of the compound is shown through the following formula in the specification. The preparation method includes the steps that at the temperature of 50 DEG C, trimethylchlorosilane is dripped to a solution of 1-epoxide phosphole -4-hydroxymethyl-2, 6, 7-trioxa-bicyclo [2.2.2] octane (PEPA) and an organic solvent, the temperature rises to 80 DEG C to 140 DEG C, a reaction is conducted for 5 h to 11 h through stirring, a quantitative acid-binding agent is added, stirring is conducted for 1 h, when the pH of the solution is detected as 5 to 6, the reaction is ended, after reduced pressure distillation, purification treatment is conducted, and then cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester is acquired. The compound is an excellent halogen-free phosphorus and silicon synergistic flame-retardant charring agent, can be applied to polyolefin, polyester, polyvinyl chloride, polyurethane, epoxy resin, unsaturated polyester resin and the like, and is simple in process and small in equipment investment, and industrial production can be easily achieved.
Owner:SHANDONG XINGQIANG CHEM IND TECH RES INST CO LTD
A kind of supercritical method prepares nano-phosphorus-nitrogen intumescent flame retardant method
ActiveCN104961701BNarrow particle size distributionGood monodispersityOrganic chemistryBulk chemical productionDispersityMelamine phosphate
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH
A kind of method that catalyzes the synthesis of benzophosphole with pd nanoparticle
InactiveCN108558949BGood choiceEase of industrial productionGroup 5/15 element organic compoundsCatalyst activation/preparationOrganic synthesisFluorescence
The invention provides a novel method using Pd nano particles to catalytically synthesize benzophosphole and belongs to the field of organic synthesis. The method includes: the new Pd nano particles are synthesized first, a compound I is used as the reaction substrate, and cyclization is performed to obtain the target compound II as shown in the specification, wherein R1 and R2 represent phenyl, substituted phenyl or C1-5 alkyl. The method has the advantages that the method is good in selectivity, product yield can reach above 89%, industrial production is facilitated, and application of the benzophosphole in fields such as organic light-emitting functional materials (solar cells and organic light-emitting diodes), photochromic molecular switches and biological fluorescent probes.
Owner:HENAN ACADEMY OF SCI CHEM RES INST CO LTD
Benzozaphosphorophosphine oxygen ligand and its complex, preparation method and application
ActiveCN109096338BSimplify the coupling reaction processMild reaction conditionsOrganic compound preparationOrganic-compounds/hydrides/coordination-complexes catalystsArylCombinatorial chemistry
Owner:SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
Photoaffinity-labeled sphingomyelin analogs and processes thereof
A photoaffinity-labeled sphingomyelin analog of the following formula:wherein R1 is C1-20 alkylene group, R5 is C1-20 alkyl group, aryl group or C1-6 alkyl group substituted by aryl group, Z is photoaffinity-labeled group and Me is methyl group, or an optically active compound thereof.
Owner:DAISO CO LTD
Phosphole compound
ActiveUS11174389B2High fluorescence quantum yieldGroup 5/15 element organic compoundsAzo dyesArylQuantum yield
A phosphole compound represented by the formula(wherein Ar1 and Ar2 are the same or different, and represent an optionally substituted aromatic hydrocarbon ring or an optionally substituted heteroaromatic ring; Ar3 represents a divalent π-conjugated unit; R1 represents an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group; R2 and R3 are the same or different, and represent a hydrogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group; and Z represents a reactive group) can provide a fluorescent dye capable of maintaining a high fluorescence quantum yield irrespective of solvent polarity, and providing an improved fluorescence quantum yield and light resistance even in environments containing large amounts of water.
Owner:NAGOYA UNIVERSITY
Synthesis and anticancer activity of conjugated phospholipid compounds
InactiveCN1136226CExcellent tumor inhibition rateImprove tumor inhibitionOrganic active ingredientsSugar derivativesAdenocarcinomaSulfur
The phospholipid compound is synthesized through reaction of P(NEt2)3, N3-(beta-ethoxyl) Tegafur, Rac-2-0-alkyl glycerine and monomer sulfur. It has a mouse LA795 lung adenocarcinoma inhibiting rate of 97.4% and a mouse liver cancer inhibiting rate of 81% in the dosage of 50 mM / Kg, higher than 61.4% and 60.5% separately of Tegafur. The present invention has novel and reasonable synthesizing process and high yield.
Owner:NANKAI UNIV
Large-pi conjugated phosphorus-doped fused ring compound as well as preparation method and application thereof
PendingCN121248677AGroup 5/15 element organic compoundsPhotovoltaic energy generationOrganic synthesisOrganic base
The invention discloses a large-pi conjugated phosphorus-doped fused ring compound as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: by adopting a series strategy of combining visible light catalysis and acid treatment, carrying out dehydrophosphine free radical addition / cyclization reaction on commercially available bicycloolefin and a secondary phosphine oxide compound serving as raw materials under the irradiation of visible light in the presence of cobalt oxime complex catalysis and organic alkali to generate a phosphorus heterocyclic intermediate; then the intermediate is heated and refluxed in concentrated hydrochloric acid for deoxidation aromatization, and large-pi conjugated phosphorus-doped condensed ring structures such as naphthalene ring benzo-phosphorus cyclopentadiene are efficiently constructed. The method provided by the invention overcomes the defects of tedious steps and large substrate limitation of the traditional alkyne route, has the advantages of mild reaction conditions, simple operation, good to excellent yield (up to 70-90%), and realization of one-pot synthesis, and is suitable for large-scale production. A series of prepared novel phosphorus-doped fused ring compounds show strong fluorescence under ultraviolet irradiation, and have application potential in the field of organic photoelectric materials.
Owner:WUHAN RES INST OF MATERIALS PROTECTION
Enhancement of magenesium uptake in mammals
InactiveUS20110183034A1Enhancing magnesium uptakeMetabolism disorderAnimal feeding stuffMagnesium saltCarboxylic acid
Disclosed are methods and complexes for increasing magnesium uptake in mammals. Increasing magnesium uptake in mammals is accomplished by concurrently administering one or more magnesium salts with one or more quaternary amines and / or phosphatides and one or more di- or tri-carboxylic acids.
Owner:JAFFE RUSSELL
A kind of organic electroluminescent compound containing bisphosphole condensed ring and its synthesis method
InactiveCN108558948BLower LUMO OrbitEasy injectionGroup 5/15 element organic compoundsLuminescent compositionsCharge injectionOrganic electroluminescence
The invention discloses an organic electroluminescence compound with a diphosphopentadiene condensed ring and a synthesis method of the compound, and belongs to organophosphorus electroluminescence materials. The compound has a structure general formula as shown in a formula (I), wherein E is O or S, and a pi-conjugated group is phenyl or thiophene and the like. The compound can serve as a luminescent layer of an organic electroluminescence device to be applied to electroluminescence devices, luminescence properties of the device can be effectively changed by simply and chemically modifying phosphorus atoms and changing the pi-conjugated group, adjustment and control from blue light to yellow light are achieved, the compound is good in heat stability, natures of cis-trans-isomer devices are almost indistinguishable, the cis-trans-isomer devices has excellent charge injection and transmitting capacity, and the efficiency and the service lives of the corresponding organic electroluminescence devices can be remarkably improved.
Owner:HENAN ACADEMY OF SCI CHEM RES INST CO LTD
Phosphole compound
ActiveUS20190264031A1High fluorescence quantum yieldGroup 5/15 element organic compoundsAzo dyesArylQuantum yield
A phosphole compound represented by the formula(wherein Ar1 and Ar2 are the same or different, and represent an optionally substituted aromatic hydrocarbon ring or an optionally substituted heteroaromatic ring; Ar3 represents a divalent π-conjugated unit; R1 represents an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group; R2 and R3 are the same or different, and represent a hydrogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group; and Z represents a reactive group) can provide a fluorescent dye capable of maintaining a high fluorescence quantum yield irrespective of solvent polarity, and providing an improved fluorescence quantum yield and light resistance even in environments containing large amounts of water.
Owner:NAGOYA UNIVERSITY
Lipoid bio-degradable polyester and preparation thereof
Owner:FUDAN UNIV
Synthesis of Glycerolipid Carbamates and Dicarbamates and Their Use as an Antitumor Compounds
The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a glycerol backbone, a carbamate, dicarbamate, or ureido moiety at the C-2 position of the glycerol backbone, and a phosphocholine, phosphonocholine, or glycoside moiety at the C-3 position of the glycerol backbone are described. The synthesis and antiproliferative activity of ether lipids with a naphthol moiety at the C-1 position are also described. These compounds were shown to be potent inhibitors of cancer cell growth. These compounds are useful for killing cancer cells and treating cancer.
Owner:UNIVERSITY OF MANITOBA +1