The invention belongs to the technical field of medical materials, and discloses a 
wound exudate responsive controlled released 
hydrogen sulfide probe and a preparation method and application thereof. The 
wound exudate responsive controlled released 
hydrogen sulfide probe is more than one of a formula I or a formula II; R in the formula I and R in the formula II are respectively 
phenylene, thienyl, furylidene, pyrrolidene and phosphoropentadiene without two 
hydrogen atoms; R1 and R2 are independent hydrogen, C1-6 
alkyl groups, C1-6 alkyloxy groups and C1-6 
alkyl sulfenyl groups. The method comprises the following steps: 1) dissolving a precursor compound in an 
organic solvent to obtain a precursor compound solution; preparing a compound containing S < 2-> or HS <-> into a solution to obtain a 
sulfur-containing solution; and 2) mixing the precursor compound solution with a 
sulfur-containing solution to obtain the probe. The probe provided by the invention can realize quick and efficient release of 
hydrogen sulfide in response to 
wound exudate or water and real-time self-monitoring; the wound repair can be promoted, and the repair effect is good.