This invention relates to the field of intelligent medical devices and precision
drug delivery technology, and discloses a biofluid-assisted intelligent
drug release triggering and control method that responds to the wound microenvironment. The method includes: collecting multi-parameter sensor signals such as pH, temperature, and biomarker concentration from the wound microenvironment, and performing preprocessing and
feature extraction; calculating a fusion trigger index based on a dynamic weighted fusion
algorithm to generate graded release level signals; employing a nested outer and
inner loop dual-mode
adaptive control structure to dynamically adjust
control parameters according to the release level and real-
time deviation, generating precise drive control quantity setpoints; further, predicting wound trends based on short-term historical data, and prospectively optimizing the control target based on a clinical rule
knowledge base. This invention solves the problems of rigidity,
lag, and inaccuracy of traditional local
drug delivery methods, achieving intelligent closed-loop, adaptive, and prospective
drug release regulation for complex dynamic wound microenvironments, significantly improving
treatment efficacy and safety.