The invention discloses a multi-fiber composite wear-resistant anti-microbial woven fabric. The multi-fiber composite wear-resistant anti-microbial woven fabric is composed of warp yarns and weft yarns which are woven by an air-jet loom. The raw materials of the warp yarns and the weft yarns are made from the following components, by weight, 30 to 33 parts of polypropylene, 20 to 25 parts of down feather, 23 to 26 parts of terylene, 24 to 28 parts of chicken feather, 16 to 19 parts of shengma fiber, 13 to 17 parts of acetate rayon, 2 to 4 parts of bentonite, 0.3 to 0.5 part of zinc oxide, 0.7 to 0.9 part of nanometer zirconia powder, 3 to 6 parts of mercaptoacetic acid, 7 to 10 parts of n-Propyl acrylate, 6 to 9 parts of dipropylene glycol dibenzoate, 3 to 5 parts of ginger, 2 to 4 parts of burdock, 85 to 95 parts of 1-butyl-3-methylimidazolium acetate, 90 to 110 parts of 1- allyl-3-methylimidazolium bromide, a proper amount of water, and 5 to 8 parts of auxiliary agent. The multi-fiber composite wear-resistant anti-microbial woven fabric can be used for automotive trims, and is stiff and smooth in appearance and fashionable.