The invention belong to the technical field of preparation of multifunctional materials and relates to a preparation method of self-cleaning multifunctional graphene sponge. A technological process comprises three steps of preparation, mixing and foaming. Graphene, a photocatalyst, a flame retardant, an adhesive and a foaming aid are weighed according to set requirements, mixed with polyurethane and subjected to reaction crosslinking, and the sponge is prepared on the basis of polyurethane as a carrier with a one-step box foaming technology; the sponge has good absorption and ventilation properties, feels soft, and also has characteristics of ultrahigh strength, antistatic property, far infrared property, bacteria resistance, instantaneous deodorization property, negative ion property and the like of graphene; compared with traditional sponge, the graphene sponge has the advantages that electrical conductive and thermal properties are improved, functions of bacteria resistance, far infrared, negative ion and instant deodorization are added; the preparation process of the graphene sponge is simple, preparation efficiency and yield are high, environment-friendliness and energy conservation are achieved, and the graphene sponge can be widely applied to household products such as women's lingerie, shoes, seats of maglev trains, high-speed trains and high-grade automobiles, high-grade sofas, mattresses and the like.