The invention relates to the technical field of micro-needle transdermal delivery, in particular to a method and a device for soft 
capsule micro-jet type micro-needle transdermal delivery. The 
drug deliver device comprises a soft 
capsule which is used for storing 
medicine liquid, a micro-jet micro-needle unit which is capable of undergoing mechanical reciprocating vibration, a fixing unit and a controller, wherein one side of the soft 
capsule is bonded with and connected to a membrane of the micro-jet micro-needle unit and the other side of the soft capsule is bonded with and connected to the fixing unit; the micro-jet micro-needle unit is connected to the controller by virtue of a 
signal line; and the controller is used for controlling a delivery dosage of the 
medicine liquid and for controlling the micro-jet micro-needle unit to do mechanical reciprocating vibration before each 
drug delivery. With the implementation of the method disclosed by the invention, by precisely controlling the 
drug delivery dosage and by controlling the micro-jet micro-needle unit to do mechanical reciprocating vibration before each 
drug delivery, various pores can generate in 
skin cuticula, which is conducive to the 
medicine liquid to permeate 
skin epidermis; and in addition, the device disclosed by the invention can achieve change the medicine liquid safely without 
pollution, and the device is simple and convenient to operate and use.