The invention discloses a pipe blind hole-based drilling and milling machine tool capable of realizing multi-station machining, and belongs to the field of machining. The pipe blind hole-based drilling and milling machine tool capable of realizing multi-station machining comprises a spindle box, a No.1 drilling and milling head, a fixing chuck, a machine tool base, horizontal adjusting seats, a No.2 drilling and milling head, linear sliding way guiding rails, a linear ball screw, a spiral chip removal machine, a chip removal trolley, a dragging servo motor, a nut and a leftward-and-rightward adjustment mechanism. According to the pipe blind hole-based drilling and milling machine tool capable of realizing multi-station machining, power is provided by the servo motor for the linear motion and the rotation motion, the linear positioning accuracy is controlled to be 0.005 mm, the rotation positioning accuracy is 5 arc minutes, and the pipe machining accuracy requirements can be met completely. According to the machine tool, participation of operators is reduced, the labor intensity is reduced, the working efficiency is improved, and the machine tool has the advantages of easiness in operation, low labor intensity, capability of saving time and labor and the like.