The invention discloses a hollow knife handle with a spindle direct-connection transmission mode adopting an ultralow-temperature medium, and belongs to the technical field of numerical-control machine tools, and relates to the hollow knife handle with the spindle direct-connection transmission mode adopting the ultralow-temperature medium. The hollow knife handle comprises a knife handle main body, a high-performance heat insulating part and a multi-layer sealing structure, wherein in the high-performance heat insulating part, a heat-insulating sleeve and a guide tube are made of a material with low temperature resistance and a low heat conduction coefficient; both the heat insulating sleeve and the guide tube are hollow structures, and are sequentially mounted in the knife handle main body to form an ultralow-temperature medium hollow channel of the knife handle device to isolate heat conduction between the ultralow-temperature medium and the knife handle main body; and in the multi-layer sealing structure, three sealing rings and a flooding plug are low-temperature-resistant sealing rings, so that multi-layer ultralow-temperature sealing is formed, and radial sealing for the ultralow-temperature medium is realized. The hollow knife handle is directly connected with a hollow type main shaft, so that function integration is good, a vaporization rate, in the knife handle, of the ultralow-temperature medium is reduced, and cooling efficiency is improved. The knife handle is free of frosting, is convenient to dismount, and is safe and reliable to operate.