The invention provides a six-freedom-degree spray coating robot which comprises a base, a waist joint, a big arm joint, a small arm joint, a three-freedom-degree obliquely crossed wrist, a spray gun support, flanges, bearings, a plurality of first drive mechanisms and second drive mechanisms, wherein the waist joint is movably fixed to the base, the big arm joint is movably fixed to the waist joint, the small arm joint is movably fixed to the big arm joint, the three-freedom-degree obliquely crossed base is movably fixed to the small arm joint, the spray gun support is connected to the tail end of the three-freedom-degree obliquely crossed wrist, and the flanges and the bearings are movably connected among all the joints or between the joints and the wrist. The first drive mechanisms are used for driving the waist joint, the big arm joint and the small arm joint to work, and the second drive mechanisms are used for driving the three-freedom-degree obliquely crossed wrist to work. Each first drive mechanism comprises a first servo motor and an RV speed reducer. Each second drive mechanism comprises a second servo motor, a planetary reducer, a hollow transmission shaft and a gear pair, wherein the planetary reducer is connected with the second servo motor, the hollow transmission shaft is connected with the planetary reducer in a matched mode, and the gear pair is arranged in the three-freedom-degree obliquely crossed wrist and connected with the hollow transmission shaft.