The invention provides a power transformation cabinet with the fault self-checking function. The power transformation cabinet is high in fault handling efficiency and low in operational risk. The power transformation cabinet comprises a voltage transformation module, a high-voltage module, a low-voltage module, a first external connection terminal, a second external connection terminal, a fault detection module, a storage module, a control module, an alarm module, a display module and an independent power source. The voltage transformation module is respectively connected with the high-voltage module and the low-voltage module, the first external connection terminal is connected with the high-voltage module and used for externally transmitting or receiving high-voltage electricity, the second external connection terminal is connected with the low-voltage module and used for externally transmitting or receiving low-voltage electricity, the fault detection module is respectively connected with the voltage transformation module, the high-voltage module and the low-voltage module for fault detection, a fault factor contrast data base is preset in the storage module and used for storing factors which cause faults and correspond to various fault expressive forms and the corresponding relations, and the control module is respectively connected with the fault detection module, the storage module, the alarm module and the display module.