The invention relates to a closed spray cooling experiment system suitable for various cooling madia, belongs to the field of high-efficiency heat exchange and aims to solve the problem of the lack ofan experiment table which is simple to operate and multiparameter-adjustable in the research field of spray cooling technology. The system mainly comprises a gas-liquid separator (1), a compressor (2), a refrigerant liquid storage tank (3), a first stop valve (4), a pre-cooler (5), a refrigerant condenser (6), a drying filter (7), a bypass regulating valve (8), a first flow regulating valve (9),a second stop valve (10), a flowmeter (11), a spray chamber (12), an auxiliary electric heater (13), a third stop valve (14), a second flow regulating valve (15), a filter (16), a pump (17), a non-refrigerant liquid storage tank (18), a fourth stop valve (19) and a non-refrigerant condenser (20). The system has multiple advantages that spray cooling experiments using various liquids and various refrigerants as media can be conducted, the cooling media can be recycled, multiple parameters can be adjusted, use is convenient and the like.