The invention provides an injection and molding typed multipurpose shaft seal without shutdown, belonging to the shaft end sealing technical field. The structure of the invention comprises a sealing body in first grade or higher than the first grade; the sealing body in each grade is internally provided with an injection molding hole; the end of the injection molding hole is communicated with the a cirque sealing chamber which is enclosed by the sealing body and a rotation shaft; the two sides of the cirque sealing chamber are provided with a packing chamber; corresponding sealing grease, sealing paste, sealing liquid or solid sealing material can be selectively injected into the injection molding hole according to different sealing parts, pressure and medium, thus preventing the internal and external leakage of the shaft seal. Compared with the prior art, the injection and molding typed multipurpose shaft seal without shutdown of the invention can be widely applied to the shaft end sealing of various rotation equipments in positive pressure and negative pressure, such as steam turbine, generator, water pump, fan, gearbox, etc., and can also be combined with the traditional seals, such as labyrinth seal, packing seal, mechanical seal, magnetic seal, etc. The invention can realize the overall sealing between the sealing body and the shaft, between the sealing body and a sealing sleeve, and between the sealing sleeve and the equipment. The invention can be suitable for the shaft seal of the equipment which is not concentric with the shaft. The sealing body and the sealing sleeve can be made into taper, thus realizing self sealing.