The invention provides a polyurethane nubuck resin for high-resilience high-velvet-feeling clothing leather and a preparation method thereof. The polyurethane nubuck resin for the high-resilience high-velvet-feeling clothing leather is prepared from, by weight, 4.0-12% of isocyanate, 16-22% of mixed polyvalent alcohol, 1.0-2.5% of chain extender, 65-80% of N,N-dimethylformamide, 0.1-0.5% of auxiliary, 1.0-2.0% of polypropylene oxide glycol (PPG) and 0.05-0.5% of methyl alcohol. The polyurethane nubuck resin for the high-resilience high-velvet-feeling clothing leather is prepared through the synthesis technology of polybutylene adipate-diethylene glycol ester diol, polycarbonate diol, silicon oil, diisocyanate, other reactants and two midbodies in an independent chain growth mode, and the prepared resin is used for polyurethane nubuck leather. The prepared nubuck leather has the advantages of being high in resilience, uniform in bubble thickness, strong in velvet feeling, good in weather resistance and the like.