The invention discloses a method for controlling the internal quality of a 37Mn circular tube steel casting blank with a phi-280mm production section, and belongs to the field of metallurgy. The method comprises the steps such as smelting in a converter, molten steel refining in an LF furnace, RH vacuum treatment and continuous casting of molten steel. First of all, the purity of the molten steel is improved according to reasonable parameter control in the molten steel smelting stage, and the high-temperature plasticity of the molten steel is improved and the steel grade crack sensitivity is lowered after the molten steel is subjected to titanium microalloying; and then, mold electromagnetic stirring and final electromagnetic stirring are combined in the molten steel pouring stage, so that component and temperature homogenization of the molten steel can be achieved, the shell of the circular tube steel casting blank can grow uniformly, the solidification structure of the circular tube steel casting blank can be effectively improved, the loose level can be raised, the area of an equiaxial crystal region can be enlarged, the compactness of the central region of the circular tube steel casting blank can be effectively improved, the crack defect of the circular tube steel casting blank can be effectively controlled, the surface non-clearing rate can be improved, and the quality of such a rolled product can be controlled well and stably.