The invention provides a hydrogel mask taking vinasse melanin and poplar bud total flavonoids as main raw materials. The hydrogel mask comprises gel, a flexibilizer, a skin conditioner, an emulsifier, a transdermal penetration enhancer, a stabilizer, an adhesion enhancer, a pH regulator and water, the skin conditioner comprises vinasse melanin and poplar bud general flavone. According to the prepared whitening, moisturizing, high-elasticity, support-free and environment-friendly hydrogel mask, the adopted matrix raw material components are natural, green and harmless biomacromolecules and agricultural and sideline product extracts which are good in biocompatibility and excellent in skin affinity, the mask is safe and harmless to the human body, it is guaranteed that the mask matrix is free of sensitization, and the mask can be used for whitening, moisturizing, moisturizing and the like. The prepared mask has the characteristics of good adhesion and fitness, excellent stretchability and toughness, excellent moisturizing and whitening effects, good stripping integrity and the like. The vinasse and poplar bud agricultural and sideline product resources with a large inventory can be comprehensively utilized, the production cost can be reduced, and the economic benefits of the vinasse and the poplar buds are increased.