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Biological scaffolds derived from extracellular matrix (ECM) have been widely utilised in regenerative medicine. The ECM is an essential non-cellular component of the tissue microenvironment, comprised of a network of macromolecules including polysaccharide glycosaminoglycans (GAGs) and proteins such as collagens, laminins, and fibronectin.
Fast automated approach for the derivation of acellular extracellular matrix scaffolds from tissues
ActiveUS12623002B2Bioreactor/fermenter combinationsBiological substance pretreatmentsCell-Extracellular MatrixECM Protein
Provided herein are systems, devices and methods to automate and optimize the decellularization process of representative tissues, such as soft tissues, for extracellular matrix (ECM)-based scaffold and biomaterial production. The automated decellularization processes and devices significantly reduce the exposure time to reagents, minimize lot-to-lot variability, and largely preserve the native composition of the ECM from the decellularized tissue or species.
Owner:NORTH CAROLINA STATE UNIV