The invention relates to the fields of
chemical synthesis and biological representation, and more particularly, provides a preparation method and an application of a pH-responsive amphiphilic rod-likepolymer
prodrug, which is represented as the drawing in the specification. The preparation method of the amphiphilic rod-like
polymer material includes the following steps: 1) synthesizing a rod-likeATRP initiator on the basis of
glucan; 2) introducing a pH-responsive hydrophobic block on the basis of ATRP reaction; 3) introducing a hydrophilic block on the basis of ATRP reaction to obtain an amphiphilic
polymer material; 4) substituting an ester group on the terminal of MGMA by means of hydrazine
hydrate, thus producing a pH-responsive precursor; 5) forming a
hydrazone bond by means of a
carbonyl group on adriamycin and an amino group on the
polymer material, thus producing the pH-
responsive polymer prodrug. By means of weak acidity of interior of
cancer cells, the amphiphilic rod-likepolymer
prodrug can selectively release a
drug by means of pH-stimulating response. The polymer prodrug is high in
micelle stability, is high in
drug carrying capacity and enables
drug release to be under stimulating
response control.